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Construction and Evaluation of Scopolamine Ion- Selective Electrode

Analytical Chemistry Department, Faculty of Pharmacy - Zagazig University, Zagazig, Egypt
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Sci. Pharm. 2000, 68(3), 247-261; https://doi.org/10.3797/scipharm.aut-00-23
Received: 24 February 2000 / Revised: 6 June 2000 / Accepted: 6 June 2000 / Published: 6 July 2000
The construction of plasticised PVC matrix-type scopolamine ion- selective membrane electrode and its use in the potentiometric determination of scopolamine in pharmaceutical preparations are described. It is based on the use of tlie ion-associate species, fonned by scopolainine cation and 5-nitrobarbitoric counter ion. The basic electrode peifonnance characteristics are evaluated according to IUPAC I-ecoininendatioiis. It exhibited a linear response for 1x10-2–1x10-5 M of scopolamine solutions with a cationic Nernstian slope over the pH range of 4-7. Common organic and inorganic cations showed negligible interference. Direct potentiometric determination of 1x10-2–1x10-5 M aqueous tubocurarine chloride using this membrane electrode system showed an average recovery of 99.05 with a mean standard deviation of 0.12. This electrode system was successfully applied to the potentiometric determination of scopolamine in some pharmaceutical preparations.
Keywords: Scopolamine membrane electrode; potentiometry; pharmaceutical analysis Scopolamine membrane electrode; potentiometry; pharmaceutical analysis
MDPI and ACS Style

Shalaby, A.; El-Maamly, M.; Abdellatef, H. Construction and Evaluation of Scopolamine Ion- Selective Electrode. Sci. Pharm. 2000, 68, 247-261.

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