The Role of Statins in the Management of Patients Undergoing Coronary Artery Bypass Grafting
1
Department of Cardiothoracic Surgery, Heart Center, University Hospital Cologne, 50937 Cologne, Germany
2
First Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA Hospital, 54636 Thessaloniki, Greece
*
Author to whom correspondence should be addressed.
Diseases 2018, 6(4), 102; https://doi.org/10.3390/diseases6040102
Received: 13 October 2018 / Revised: 3 November 2018 / Accepted: 8 November 2018 / Published: 11 November 2018
(This article belongs to the Special Issue New Lipid Lowering Therapies for Cardiovascular and Metabolic Diseases: Lessons from the Past and Future Challenges)
Each year, a large number of patients undergo coronary artery bypass grafting surgery (CABG) worldwide. Accumulating evidence suggests that the preoperative administration of statins might be useful in preventing adverse events after CABG. In the present review, we discuss the role of statins in the perioperative management of patients undergoing CABG. Preoperative administration of statins in these patients substantially reduces the risk of postoperative atrial fibrillation and shortens hospital and intensive care unit (ICU) stay. Atorvastatin appears to be more effective, particularly when administered at high doses. Given these benefits and the safety of statins, their administration should be considered in patients undergoing CABG, even though the statins do not appear to affect the incidence of cardiovascular events and overall mortality perioperatively.
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Keywords:
statins; coronary artery bypass grafting; pleiotropic actions; atrial fibrillation; stroke; acute kidney injury
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Siskos, D.; Tziomalos, K. The Role of Statins in the Management of Patients Undergoing Coronary Artery Bypass Grafting. Diseases 2018, 6, 102. https://doi.org/10.3390/diseases6040102
AMA Style
Siskos D, Tziomalos K. The Role of Statins in the Management of Patients Undergoing Coronary Artery Bypass Grafting. Diseases. 2018; 6(4):102. https://doi.org/10.3390/diseases6040102
Chicago/Turabian StyleSiskos, Dimitrios; Tziomalos, Konstantinos. 2018. "The Role of Statins in the Management of Patients Undergoing Coronary Artery Bypass Grafting" Diseases 6, no. 4: 102. https://doi.org/10.3390/diseases6040102
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