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Diseases 2018, 6(3), 65; https://doi.org/10.3390/diseases6030065

Urinary Tract Infections among Bladder Outlet Obstruction Patients in Accra, Ghana: Aetiology, Antibiotic Resistance, and Risk Factors

1
Department of Medical Microbiology, School of Biomedical and Allied Health Sciences, University of Ghana, 00233 Accra, Ghana
2
Department of Surgery, School of Medicine and Dentistry, University of Ghana, 00233 Accra, Ghana
3
Department of Microbiology, Korle-Bu Teaching Hospital, 00233 Accra, Ghana
*
Author to whom correspondence should be addressed.
Received: 11 June 2018 / Revised: 5 July 2018 / Accepted: 10 July 2018 / Published: 19 July 2018
(This article belongs to the Section Infectious Disease)
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Abstract

The aim of this study was to investigate urinary tract infections among patients with Bladder Outlet Obstruction (BOO) at the Korle Bu Teaching Hospital (KBTH) in Accra, Ghana, including the prevalence, risk factors, aetiological agents and their antibiogram. Urine specimens were collected from 188 male patients presenting with BOO and cultured for bacteria. The bacterial isolates were identified using standard microbiological methods and tested against a spectrum of antimicrobial agents using the Kirby Bauer method. Demographic information and the clinical history of study participants were also recorded. The prevalence of urinary tract infection among the BOO patients was 76.6% and the main risk factor identified was catheterization (p < 0.0001). A wide range of bacterial organisms was isolated from urine specimens and they were predominantly, Enterobacteriaceae; Escherichia coli was the most frequent cause of bacteriuria (33.3%), followed by Klebsiella (17.3%). Bacterial isolates were most resistant to Augmentin (97.8%) followed by tetracycline (85.8%), nalidixic acid (82.8%) and ciprofloxacin (75%) while 93.6% were multi-drug resistant. The highest susceptibility was observed with amikacin, which had a resistance prevalence of 4.4% resistance. These findings have important implications in the treatment of urinary tract infections among the BOO patients in Ghana. View Full-Text
Keywords: Bladder Outlet Obstruction; urinary tract infection; catheterization; E. coli; multi-drug resistant Bladder Outlet Obstruction; urinary tract infection; catheterization; E. coli; multi-drug resistant
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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MDPI and ACS Style

Asafo-Adjei, K.; Mensah, J.E.; Labi, A.-K.; Dayie, N.T.K.D.; Donkor, E.S. Urinary Tract Infections among Bladder Outlet Obstruction Patients in Accra, Ghana: Aetiology, Antibiotic Resistance, and Risk Factors. Diseases 2018, 6, 65.

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