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Open AccessArticle

Early Detection for Dengue Using Local Indicator of Spatial Association (LISA) Analysis

Grupo de Análisis Funcional y Aplicaciones, Universidad EAFIT, Carrera 49 No. 7 Sur-50, Medellín 050022, Colombia
Grupo Biología y Control de Enfermedades Infecciosas—BCEI, Universidad de Antioquia, Calle 70 No. 52-21, Medellin 050010, Colombia
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Diseases 2016, 4(2), 16;
Received: 18 January 2016 / Revised: 21 March 2016 / Accepted: 25 March 2016 / Published: 29 March 2016
(This article belongs to the Section Infectious Disease)
Dengue is a viral disease caused by a flavivirus that is transmitted by mosquitoes of the genus Aedes. There is currently no specific treatment or commercial vaccine for its control and prevention; therefore, mosquito population control is the only alternative for preventing the occurrence of dengue. For this reason, entomological surveillance is recommended by World Health Organization (WHO) to measure dengue risk in endemic areas; however, several works have shown that the current methodology (aedic indices) is not sufficient for predicting dengue. In this work, we modified indices proposed for epidemic periods. The raw value of the epidemiological wave could be useful for detecting risk in epidemic periods; however, risk can only be detected if analyses incorporate the maximum epidemiological wave. Risk classification was performed according to Local Indicators of Spatial Association (LISA) methodology. The modified indices were analyzed using several hypothetical scenarios to evaluate their sensitivity. We found that modified indices could detect spatial and differential risks in epidemic and endemic years, which makes them a useful tool for the early detection of a dengue outbreak. In conclusion, the modified indices could predict risk at the spatio-temporal level in endemic years and could be incorporated in surveillance activities in endemic places. View Full-Text
Keywords: dengue risk classification; early warning; spatial analysis; temporal indices dengue risk classification; early warning; spatial analysis; temporal indices
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MDPI and ACS Style

Parra-Amaya, M.E.; Puerta-Yepes, M.E.; Lizarralde-Bejarano, D.P.; Arboleda-Sánchez, S. Early Detection for Dengue Using Local Indicator of Spatial Association (LISA) Analysis. Diseases 2016, 4, 16.

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