Incidence and Prognostic Factors for Colectomy in Acute Severe Ulcerative Colitis with Concomitant CMV Infection
Abstract
1. Introduction
2. Materials and Methods
3. Results
3.1. Study Population
3.2. Colectomy Rates During the Follow-Up Period
3.3. Prognostic Factors of Colectomy Following CMV Intestinal Infection
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
UC | Ulcerative Colitis |
IBD | Inflammatory Bowel Disease |
ASUC | Acute Severe Ulcerative Colitis |
CMV | Cytomegalovirus |
IHC | Immunohistochemistry |
PCR | Polymerase Chain Reaction |
PROs | Patient-Reported Outcomes |
UCEIS | Ulcerative Colitis Endoscopic Index of Severity |
Anti-TNF | Anti-Tumor Necrosis Factor |
MAdCAM-1 | Mucosal Addressin Cell Adhesion Molecule-1 |
NK cells | Natural Killer Cells |
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Age in Years [Mean (SD)] | 47.0 (18.5) |
---|---|
Male [n (%)] | 30 (66.7) |
Disease duration [median (IQR)] | 3 (1–7.5) |
Montreal [n (%)] | |
E2 | 14 (31.1) |
E3 | 31 (68.9) |
EIMs [n (%)] | 12 (26.7) |
Family history [n (%)] | 2 (4.4) |
Treatment at infection [n (%)] | |
Corticosteroids | 23 (51.1) |
Immmunomodulators | 8 (17.8) |
Biologics | 26 (57.8) |
Anti-TNF | 15 (33.3) |
Vedolizumab | 7 (15.6) |
Tofacitinib | 4 (8.9) |
Clinical scores [median (IQR)] | |
PRO-Rectal bleeding | 2 (2–3) |
PRO-Bowel movement | 2 (2–3) |
Urgency | 1 (1–1.8) |
Endoscopic findings | |
Endoscopic MAYO [median (IQR)] | 3 (2–3) |
UCEIS [median (IQR)] | 6 (5–6) |
Deep ulcers [n (%)] | 25 (55.6) |
Laboratory findings | |
Hemoglobin g/dL [mean (SD)] | 12.5 (1.9) |
Platelets × 109/L [mean (SD)] | 327 (100) |
White blood cells × 109/L [mean (SD)] | 9748 (3267) |
CRP mg/L [median (IQR)] | 15.8 (5.9–36.1) |
Albumin g/dL [mean (SD)] | 3.8 (0.6) |
Univariate | Multivariate | |||||
---|---|---|---|---|---|---|
OR | 95% CI | p | OR | 95% CI | p | |
Age less than 54 years | 4.05 | 1.18–13.85 | 0.026 | 0.69 | 0.14–3.48 | 0.648 |
Receiving vedolizumab at diagnosis | 3.80 | 1.11–12.99 | 0.034 | 24.46 | 2.31–259.5 | 0.008 |
PRO-Rectal Bleeding = 3 | 3.19 | 0.85–12.04 | 0.087 | 1.72 | 0.21–14.07 | 0.613 |
PRO-Bowel movement = 3 | 6.12 | 1.32–28.39 | 0.021 | 5.42 | 0.42–69.67 | 0.195 |
Deep ulcers at endoscopy | 3.86 | 0.84–17.89 | 0.084 | 2.65 | 0.48–14.75 | 0.267 |
Hemoglobin < 12 g/dL | 3.23 | 0.94–11.08 | 0.062 | 8.73 | 1.22–62.48 | 0.031 |
Albumin < 3.8 g/dL | 3.47 | 0.90–13.44 | 0.072 | 2.40 | 0.44–12.98 | 0.310 |
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Kitsou, K.; Chalakatevaki, K.; Kokkotis, G.; Papathanasiou, E.; Kitsou, V.; Michopoulos, S.; Zampeli, E.; Bamias, G. Incidence and Prognostic Factors for Colectomy in Acute Severe Ulcerative Colitis with Concomitant CMV Infection. Diseases 2025, 13, 321. https://doi.org/10.3390/diseases13100321
Kitsou K, Chalakatevaki K, Kokkotis G, Papathanasiou E, Kitsou V, Michopoulos S, Zampeli E, Bamias G. Incidence and Prognostic Factors for Colectomy in Acute Severe Ulcerative Colitis with Concomitant CMV Infection. Diseases. 2025; 13(10):321. https://doi.org/10.3390/diseases13100321
Chicago/Turabian StyleKitsou, Konstantina, Konstantina Chalakatevaki, Georgios Kokkotis, Evgenia Papathanasiou, Vassiliki Kitsou, Spyridon Michopoulos, Evanthia Zampeli, and Giorgos Bamias. 2025. "Incidence and Prognostic Factors for Colectomy in Acute Severe Ulcerative Colitis with Concomitant CMV Infection" Diseases 13, no. 10: 321. https://doi.org/10.3390/diseases13100321
APA StyleKitsou, K., Chalakatevaki, K., Kokkotis, G., Papathanasiou, E., Kitsou, V., Michopoulos, S., Zampeli, E., & Bamias, G. (2025). Incidence and Prognostic Factors for Colectomy in Acute Severe Ulcerative Colitis with Concomitant CMV Infection. Diseases, 13(10), 321. https://doi.org/10.3390/diseases13100321