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Electronics 2018, 7(8), 133;

Multiple Wavelength Optical Coherence Tomography Assessments for Enhanced Ex Vivo Intra-Cochlear Microstructural Visualization

School of Electronics Engineering, College of IT Engineering, Kyungpook National University, 80, Daehak-ro, Buk-gu, Daegu 41566, Korea
Department of Biomedical Engineering, College of Engineering, Kyungil University, 50, Gamasil-gil, Hayang-eup, Gyeongsan-si, Gyeongsangbuk-do 38428, Korea
Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Waehringer Guertel 18–20, A-1090 Vienna, Austria
Institute of Biomedical Engineering, School of Medicine, Kyungpook National University, 680, Gukchaebosang-ro, Jung-gu, Daegu 41944, Korea
Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Ajou University, 164 World cup-ro, Yeongtong-gu, Suwon, Gyeonggi-do 41944, Korea
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 30 June 2018 / Revised: 23 July 2018 / Accepted: 28 July 2018 / Published: 31 July 2018
Full-Text   |   PDF [5608 KB, uploaded 31 July 2018]   |  


The precise identification of intra-cochlear microstructures is an essential otorhinolaryngological requirement to diagnose the progression of cochlea related diseases. Thus, we demonstrated an experimental procedure to investigate the most optimal wavelength range, which can enhance the visualization of ex vivo intra-cochlear microstructures using multiple wavelengths (i.e., 860 nm, 1060 nm, and 1300 nm) based optical coherence tomography (OCT) systems. The high-resolution tomograms, volumetric, and quantitative evaluations obtained from Basilar membrane, organ of Corti, and scala vestibule regions revealed complementary comparisons between the aforementioned three distinct wavelengths based OCT systems. Compared to 860 nm and 1300 nm wavelengths, 1060 nm wavelength OCT was discovered to be an appropriate wavelength range verifying the simultaneously obtainable high-resolution and reasonable depth range visualization of intra-cochlear microstructures. Therefore, the implementation of 1060 nm OCT can minimize the necessity of two distinct OCT systems. Moreover, the results suggest that the performed qualitative and quantitative analysis procedure can be used as a powerful tool to explore further anatomical structures of the cochlea for future studies in otorhinolaryngology. View Full-Text
Keywords: optical coherence tomography (OCT); optical imaging; intra-cochlear microstructures; otorhinolaryngology optical coherence tomography (OCT); optical imaging; intra-cochlear microstructures; otorhinolaryngology

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Kim, S.; Wijesinghe, R.E.; Lee, J.; Shirazi, M.F.; Kim, P.; Jang, J.H.; Jeon, M.; Kim, J. Multiple Wavelength Optical Coherence Tomography Assessments for Enhanced Ex Vivo Intra-Cochlear Microstructural Visualization. Electronics 2018, 7, 133.

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