On the Selectivity of Planar Microwave Glucose Sensors with Multicomponent Solutions

Round 1

Reviewer 1 Report

This paper presents the selectivity of microwave planar resonant sensors when measuring multi-component solutions. The article is well-written and presented in a logical way. However, I have some concerns:

·         The authors could explain the response of the 2RS structure shown in Figure 4 in more detail.

·         Is chosen biomarkers equivalent to the human tissue biomarker, please elaborate it.

·         What is the formula for glucose and D (+)-glucose anhydrous? What is the difference?

·         What are the peaks of NaCl with respect to frequency?

·         Why the authors have fixed NaCl concentration. If, NaCl changes what is the effect of glucose concentration and selectivity?

·         The authors may explain the reason for choosing a 5μL sample for measurement,

 

·         Does the authors have compared the measured sample with any real-time capillary or venous blood sample of the same quantity? If yes, please mention your observations.

Author Response

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Reviewer 2 Report

 

1.      In the 2^nd paragraph, the authors here should discuss about what technologies have been done in the literature. The authors didn’t seem to introduce electrical method and enzyme-based and non-enzyme based sensors. (for example,  https://doi.org/10.3390/s20041098) And what are the pros and cons of these technologies. Microwave planar technology is non enzymatic, which is of great benefit.

2.      It could be better to fucus on industrial applications since albumin highly affects the proposed sensors’ sensitivity.

3.      I also suggest adding an experiment to further demonstrate the sensor with the best sensitivity can be used to measure unknown samples or real samples (like juices).

4.      Fig. 5-8, what is the point of presenting both 2D and 3D images?

5.      What is the glucose limit of detection of the sensors? Usually, what is the concentration range such as juices in industry?

6.      Lack of comparison to previous works .

7.      The R square for 2RS is 0.8707. Is this a good fit?

8.      Is there A1 solution with albumin 1.0 g/100g concentration?

Author Response

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Author Response File: Author Response.pdf

Round 2

Reviewer 2 Report

The authors have addressed most of my concerns. I would suggest acceptance of this manuscript after minor revision.

1.About the glucose concentration , I would suggest using mg/dL (or mM/L) all through the manuscript rather than g/100g like most papers do in literature.

2. Fig. 5-7, if 2D graphs are enough to present all the information, there's not much meaning to add 3D graphs. It is better to avoid redundancy. 

 

 

Author Response

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