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Article

Numerical Simulations of Light Scattering in Soft Anisotropic Fibrous Structures and Validation of a Novel Optical Setup from Fibrous Media Characterization

1
Fondazione Toscana Gabriele Monasterio, BioCardioLab, 54100 Massa, Italy
2
Department of Information Engineering, University of Pisa, 56122 Pisa, Italy
3
Sant’Anna School of Advanced Studies, TeCIP Institute, 56124 Pisa, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Nicola Francesco Lopomo
Electronics 2021, 10(5), 579; https://doi.org/10.3390/electronics10050579
Received: 16 December 2020 / Revised: 10 February 2021 / Accepted: 24 February 2021 / Published: 2 March 2021
(This article belongs to the Special Issue Digital Twin Technology: New Frontiers for Personalized Healthcare)
The insight of biological microstructures is at the basis of understanding the mechanical features and the potential pathologies of tissues, like the blood vessels. Different techniques are available for this purpose, like the Small Angle Light Scattering (SALS) approach. The SALS method has the advantage of being fast and non-destructive, however investigation of its physical principles is still required. Within this work, a numerical study for SALS irradiation of soft biological fibrous tissues was carried out through in-silico simulations based on a Monte Carlo approach to evaluate the effect of the thickness of the specimen. Additionally, the numerical results were validated with an optical setup based on SALS technique for the characterization of fibrous samples with dedicated tests on four 3D-printed specimens with different fibers architectures. The simulations revealed two main regions of interest according to the thickness (thk) of the analyzed media: a Fraunhofer region (thk < 0.6 mm) and a Multiple Scattering region (thk > 1 mm). Semi-quantitative information about the tissue anisotropy was successfully gathered by analyzing the scattered light spot. Moreover, the numerical results revealed a remarkable coherence with the experimental data, both in terms of mean orientation and dispersion of fibers. View Full-Text
Keywords: Small Angle Light Scattering; optical characterization; biological tissues; in-silico simulations Small Angle Light Scattering; optical characterization; biological tissues; in-silico simulations
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MDPI and ACS Style

di Bartolo, F.; Vignali, E.; Gasparotti, E.; Malacarne, A.; Landini, L.; Celi, S. Numerical Simulations of Light Scattering in Soft Anisotropic Fibrous Structures and Validation of a Novel Optical Setup from Fibrous Media Characterization. Electronics 2021, 10, 579. https://doi.org/10.3390/electronics10050579

AMA Style

di Bartolo F, Vignali E, Gasparotti E, Malacarne A, Landini L, Celi S. Numerical Simulations of Light Scattering in Soft Anisotropic Fibrous Structures and Validation of a Novel Optical Setup from Fibrous Media Characterization. Electronics. 2021; 10(5):579. https://doi.org/10.3390/electronics10050579

Chicago/Turabian Style

di Bartolo, Francesco, Emanuele Vignali, Emanuele Gasparotti, Antonio Malacarne, Luigi Landini, and Simona Celi. 2021. "Numerical Simulations of Light Scattering in Soft Anisotropic Fibrous Structures and Validation of a Novel Optical Setup from Fibrous Media Characterization" Electronics 10, no. 5: 579. https://doi.org/10.3390/electronics10050579

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