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The Effect of Bacterial Endotoxin LPS on Serotonergic Modulation of Glutamatergic Synaptic Transmission

Department of Biology, Center for Muscle Biology, University of Kentucky, Lexington, KY 40506-0225, USA
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Author to whom correspondence should be addressed.
Biology 2020, 9(8), 210; https://doi.org/10.3390/biology9080210
Received: 19 June 2020 / Revised: 29 July 2020 / Accepted: 3 August 2020 / Published: 6 August 2020
(This article belongs to the Section Neuroscience)
The release of the endotoxin lipopolysaccharides (LPS) from gram-negative bacteria is key in the induction of the downstream cytokine release from cells targeting cells throughout the body. However, LPS itself has direct effects on cellular activity and can alter synaptic transmission. Animals experiencing septicemia are generally in a critical state and are often treated with various pharmacological agents. Since antidepressants related to the serotonergic system have been shown to have a positive outcome for septicemic conditions impacting the central nervous system, the actions of serotonin (5-HT) on neurons also exposed to LPS were investigated. At the model glutamatergic synapse of the crayfish neuromuscular junction (NMJ), 5-HT primarily acts through a 5-HT2A receptor subtype to enhance transmission to the motor neurons. LPS from Serratia marcescens also enhances transmission at the crayfish NMJ but by a currently unknown mechanism. LPS at 100 µg/mL had no significant effect on transmission or on altering the response to 5-HT. LPS at 500 µg/mL increased the amplitude of the evoked synaptic excitatory junction potential, and 5-HT in combination with 500 µg/mL LPS continued to promote enhanced transmission. The preparations maintained responsiveness to serotonin in the presence of low or high concentrations of LPS. View Full-Text
Keywords: lipopolysaccharide; endotoxin; Serratia marcescens; neuromodulation; serotonin; neuromuscular junction lipopolysaccharide; endotoxin; Serratia marcescens; neuromodulation; serotonin; neuromuscular junction
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MDPI and ACS Style

Bernard, J.; Greenhalgh, A.; Istas, O.; Marguerite, N.T.; Cooper, R.L. The Effect of Bacterial Endotoxin LPS on Serotonergic Modulation of Glutamatergic Synaptic Transmission. Biology 2020, 9, 210. https://doi.org/10.3390/biology9080210

AMA Style

Bernard J, Greenhalgh A, Istas O, Marguerite NT, Cooper RL. The Effect of Bacterial Endotoxin LPS on Serotonergic Modulation of Glutamatergic Synaptic Transmission. Biology. 2020; 9(8):210. https://doi.org/10.3390/biology9080210

Chicago/Turabian Style

Bernard, Jate, Abigail Greenhalgh, Oscar Istas, Nicole T. Marguerite, and Robin L. Cooper. 2020. "The Effect of Bacterial Endotoxin LPS on Serotonergic Modulation of Glutamatergic Synaptic Transmission" Biology 9, no. 8: 210. https://doi.org/10.3390/biology9080210

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