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Article

Plasma CAF22 Levels as a Useful Predictor of Muscle Health in Patients with Chronic Obstructive Pulmonary Disease

1
Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, UAE
2
Department of Physiology & Cell Biology, University of Health Sciences, Lahore 53720, Pakistan
3
Department of Biochemistry, Gomal Medical College, Dera Ismail Khan 29050, Pakistan
*
Author to whom correspondence should be addressed.
Biology 2020, 9(7), 166; https://doi.org/10.3390/biology9070166
Received: 11 June 2020 / Revised: 14 July 2020 / Accepted: 14 July 2020 / Published: 15 July 2020
(This article belongs to the Section Medical Biology)
Skeletal muscle dysfunction and reduced physical capacity are characteristic features of chronic obstructive pulmonary disease (COPD). However, the search for a reliable biomarker to assess muscle health in CODP remains elusive. We analyzed the course of hand-grip strength (HGS) and appendicular skeletal mass index (ASMI) in COPD in relation to spirometry decline and plasma extracellular heat shock protein-72 (eHSP72) and c-terminal fragment of agrin-22 (CAF22) levels. We evaluated male, 62–73 years old patients of COPD (N = 265) and healthy controls (N = 252) at baseline and after 12 and 24 months for plasma biomarkers, spirometry and HGS measurements. HGS declined significantly over time and plasma CAF22, but not eHSP72 levels, had a significant negative association with HGS and ASMI in COPD. Plasma CAF22 also had an association with walking speed and daily steps count in advanced COPD. Lower ASMI was associated with reduced HGS at all time-point. Narrow age-span of the study cohort and exclusion of lower-limb muscles from the analysis are limitations of this study. Taken together, we report that the plasma CAF22 may be a useful tool to assess muscle weakness and atrophy in COPD patients. View Full-Text
Keywords: biomarkers; COPD; muscular atrophy; skeletal muscle; spirometry biomarkers; COPD; muscular atrophy; skeletal muscle; spirometry
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MDPI and ACS Style

Qaisar, R.; Karim, A.; Muhammad, T. Plasma CAF22 Levels as a Useful Predictor of Muscle Health in Patients with Chronic Obstructive Pulmonary Disease. Biology 2020, 9, 166. https://doi.org/10.3390/biology9070166

AMA Style

Qaisar R, Karim A, Muhammad T. Plasma CAF22 Levels as a Useful Predictor of Muscle Health in Patients with Chronic Obstructive Pulmonary Disease. Biology. 2020; 9(7):166. https://doi.org/10.3390/biology9070166

Chicago/Turabian Style

Qaisar, Rizwan, Asima Karim, and Tahir Muhammad. 2020. "Plasma CAF22 Levels as a Useful Predictor of Muscle Health in Patients with Chronic Obstructive Pulmonary Disease" Biology 9, no. 7: 166. https://doi.org/10.3390/biology9070166

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