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Structural Insights into the Evolutionarily Conserved BAF Chromatin Remodeling Complex

by Ryan D. Marcum 1, Alexis A. Reyes 1,2 and Yuan He 1,2,3,*
1
Department of Molecular Biosciences, Northwestern University, 2205 Tech Drive, Evanston, IL 60208-3500, USA
2
Interdisciplinary Biological Sciences Program, Northwestern University, 2205 Tech Drive, Evanston, IL 60208-3500, USA
3
Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Northwestern University, 676 N. St. Clair, Chicago, IL 60611, USA
*
Author to whom correspondence should be addressed.
Biology 2020, 9(7), 146; https://doi.org/10.3390/biology9070146
Received: 2 June 2020 / Revised: 17 June 2020 / Accepted: 23 June 2020 / Published: 30 June 2020
(This article belongs to the Special Issue ATP-dependent Chromatin Remodeler)
The switch/sucrose nonfermentable (SWI/SNF) family of proteins acts to regulate chromatin accessibility and plays an essential role in multiple cellular processes. A high frequency of mutations has been found in SWI/SNF family subunits by exome sequencing in human cancer, and multiple studies support its role in tumor suppression. Recent structural studies of yeast SWI/SNF and its human homolog, BAF (BRG1/BRM associated factor), have provided a model for their complex assembly and their interaction with nucleosomal substrates, revealing the molecular function of individual subunits as well as the potential impact of cancer-associated mutations on the remodeling function. Here we review the structural conservation between yeast SWI/SNF and BAF and examine the role of highly mutated subunits within the BAF complex. View Full-Text
Keywords: chromatin remodeling; cancer; SWI/SNF complex; BAF complex; cryo-EM chromatin remodeling; cancer; SWI/SNF complex; BAF complex; cryo-EM
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Marcum, R.D.; Reyes, A.A.; He, Y. Structural Insights into the Evolutionarily Conserved BAF Chromatin Remodeling Complex. Biology 2020, 9, 146.

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