Phosphoinositide Lipids in Ocular Tissues
1
Departments of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
2
Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
3
Departments of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma, OK 73104, USA
4
Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
*
Author to whom correspondence should be addressed.
†
Both authors contributed equally.
Biology 2020, 9(6), 125; https://doi.org/10.3390/biology9060125
Received: 8 April 2020
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Revised: 5 June 2020
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Accepted: 9 June 2020
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Published: 12 June 2020
(This article belongs to the Section Cell Biology)
Inositol phospholipids play an important role in cell physiology. The inositol head groups are reversibly phosphorylated to produce seven distinct phosphorylated inositides, commonly referred to as phosphoinositides (PIs). These seven PIs are dynamically interconverted from one PI to another by the action of PI kinases and PI phosphatases. The PI signals regulate a wide variety of cellular functions, including organelle distinction, vesicular transport, cytoskeletal organization, nuclear events, regulation of ion channels, cell signaling, and host–pathogen interactions. Most of the studies of PIs in ocular tissues are based on the PI enzymes and PI phosphatases. In this study, we examined the PI levels in the cornea, retinal pigment epithelium (RPE), and retina using PI-binding protein as probes. We have examined the lipids PI(3)P, PI(4)P, PI(3,4)P2, PI(4,5)P2, and PI(3,4,5)P3, and each is present in the cornea, RPE, and retina. Alterations in the levels of these PIs in mouse models of retinal disease and corneal infections have been reported, and the results of our study will help in the management of anomalous phosphoinositide metabolism in ocular tissues.
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MDPI and ACS Style
Rajala, A.; McCauley, A.; Brush, R.S.; Nguyen, K.; Rajala, R.V.S. Phosphoinositide Lipids in Ocular Tissues. Biology 2020, 9, 125. https://doi.org/10.3390/biology9060125
AMA Style
Rajala A, McCauley A, Brush RS, Nguyen K, Rajala RVS. Phosphoinositide Lipids in Ocular Tissues. Biology. 2020; 9(6):125. https://doi.org/10.3390/biology9060125
Chicago/Turabian StyleRajala, Ammaji, Austin McCauley, Richard S. Brush, Khuong Nguyen, and Raju V.S. Rajala. 2020. "Phosphoinositide Lipids in Ocular Tissues" Biology 9, no. 6: 125. https://doi.org/10.3390/biology9060125
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