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Biology 2018, 7(1), 10; https://doi.org/10.3390/biology7010010

Intraperitoneal Administration of Oxygen/Ozone to Rats Reduces the Pancreatic Damage Induced by Streptozotocin

1
Department of Experimental Medicine, Division of Pharmacology, University of Campania, via S. Maria di Costantinopoli 16, 80138 Naples, Italy
2
“Maria Guarino” Foundation—AMOR No Profit Association, 80078 Pozzuoli, Italy
3
Department of Physical and Mental Health and Preventive Medicine, University of Campania, 80138 Naples, Italy
*
Author to whom correspondence should be addressed.
These authors share the first authorship.
Received: 9 November 2017 / Revised: 8 January 2018 / Accepted: 9 January 2018 / Published: 11 January 2018
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Abstract

Background: The rat model of streptozotocin (STZ)-induced pancreatic damage was used to examine whether a systemic oxygen/ozone mixture could be beneficial for the pancreas by reducing the machinery of the local detrimental mediators released by STZ. Results: The results showed that oxygen/ozone administration (150 µg/Kg i.p.) for ten days in STZ rats increased the endogenous glutathione-s-transferase (GST) enzyme and nuclear factor-erythroid 2-related factor 2 (Nrf2) into the pancreatic tissue, together with reduction of 4-hydroxynonenal (4-HNE) and PARP-1 compared to STZ rats receiving O2 only. Interestingly, these changes resulted in higher levels of serum insulin and leptin, and pancreatic glucagon immunostaining. Consequently, glucose metabolism improved as evidenced by the monitoring of glycemia throughout. Conclusions: This study provides evidence that systemic administration of oxygen/ozone reduces the machinery of detrimental mediators released by STZ into the pancreas with less local damage and better functionality. View Full-Text
Keywords: streptozotocin; ozone therapy; pancreas; rat streptozotocin; ozone therapy; pancreas; rat
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Siniscalco, D.; Trotta, M.C.; Brigida, A.L.; Maisto, R.; Luongo, M.; Ferraraccio, F.; D’Amico, M.; Di Filippo, C. Intraperitoneal Administration of Oxygen/Ozone to Rats Reduces the Pancreatic Damage Induced by Streptozotocin. Biology 2018, 7, 10.

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