Mechanisms to Avoid and Correct Erroneous Kinetochore-Microtubule Attachments

Lampson, Michael A.; Grishchuk, Ekaterina L.

doi:10.3390/biology6010001

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Mechanisms to Avoid and Correct Erroneous Kinetochore-Microtubule Attachments

by

Michael A. Lampson

^1,* and

Ekaterina L. Grishchuk

^2,*

¹

Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA

²

Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

^*

Authors to whom correspondence should be addressed.

Biology 2017, 6(1), 1; https://doi.org/10.3390/biology6010001

Submission received: 3 November 2016 / Revised: 24 December 2016 / Accepted: 28 December 2016 / Published: 5 January 2017

(This article belongs to the Special Issue Mechanisms of Mitotic Chromosome Segregation)

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Abstract

In dividing vertebrate cells multiple microtubules must connect to mitotic kinetochores in a highly stereotypical manner, with each sister kinetochore forming microtubule attachments to only one spindle pole. The exact sequence of events by which this goal is achieved varies considerably from cell to cell because of the variable locations of kinetochores and spindle poles, and randomness of initial microtubule attachments. These chance encounters with the kinetochores nonetheless ultimately lead to the desired outcome with high fidelity and in a limited time frame, providing one of the most startling examples of biological self-organization. This chapter discusses mechanisms that contribute to accurate chromosome segregation by helping dividing cells to avoid and resolve improper microtubule attachments.

Keywords: Aurora B kinase; kinetochore geometry; microtubule turnover; tension-dependent regulation

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MDPI and ACS Style

Lampson, M.A.; Grishchuk, E.L. Mechanisms to Avoid and Correct Erroneous Kinetochore-Microtubule Attachments. Biology 2017, 6, 1. https://doi.org/10.3390/biology6010001

AMA Style

Lampson MA, Grishchuk EL. Mechanisms to Avoid and Correct Erroneous Kinetochore-Microtubule Attachments. Biology. 2017; 6(1):1. https://doi.org/10.3390/biology6010001

Chicago/Turabian Style

Lampson, Michael A., and Ekaterina L. Grishchuk. 2017. "Mechanisms to Avoid and Correct Erroneous Kinetochore-Microtubule Attachments" Biology 6, no. 1: 1. https://doi.org/10.3390/biology6010001

APA Style

Lampson, M. A., & Grishchuk, E. L. (2017). Mechanisms to Avoid and Correct Erroneous Kinetochore-Microtubule Attachments. Biology, 6(1), 1. https://doi.org/10.3390/biology6010001

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Mechanisms to Avoid and Correct Erroneous Kinetochore-Microtubule Attachments

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