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Mechanisms to Avoid and Correct Erroneous Kinetochore-Microtubule Attachments

A Molecular View of Kinetochore Assembly and Function

by 1,2,* and 3,4,*
Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn Straße 11, Dortmund 44227, Germany
Centre for Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen 45117, Germany
Ludwig Institute for Cancer Research, La Jolla, CA 92093, USA
Department of Cellular & Molecular Medicine, 9500 Gilman Dr., La Jolla, CA 92093, USA
Authors to whom correspondence should be addressed.
Academic Editor: J. Richard McIntosh
Received: 13 December 2016 / Revised: 16 January 2017 / Accepted: 17 January 2017 / Published: 24 January 2017
(This article belongs to the Special Issue Mechanisms of Mitotic Chromosome Segregation)
Kinetochores are large protein assemblies that connect chromosomes to microtubules of the mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to its daughters. Kinetochores also control feedback mechanisms responsible for the correction of incorrect microtubule attachments, and for the coordination of chromosome attachment with cell cycle progression. Finally, kinetochores contribute to their own preservation, across generations, at the specific chromosomal loci devoted to host them, the centromeres. They achieve this in most species by exploiting an epigenetic, DNA-sequence-independent mechanism; notable exceptions are budding yeasts where a specific sequence is associated with centromere function. In the last 15 years, extensive progress in the elucidation of the composition of the kinetochore and the identification of various physical and functional modules within its substructure has led to a much deeper molecular understanding of kinetochore organization and the origins of its functional output. Here, we provide a broad summary of this progress, focusing primarily on kinetochores of humans and budding yeast, while highlighting work from other models, and present important unresolved questions for future studies. View Full-Text
Keywords: centromere; kinetochore; cell division; mitosis; meiosis; KMN; CCAN; CENP-A centromere; kinetochore; cell division; mitosis; meiosis; KMN; CCAN; CENP-A
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MDPI and ACS Style

Musacchio, A.; Desai, A. A Molecular View of Kinetochore Assembly and Function. Biology 2017, 6, 5.

AMA Style

Musacchio A, Desai A. A Molecular View of Kinetochore Assembly and Function. Biology. 2017; 6(1):5.

Chicago/Turabian Style

Musacchio, Andrea, and Arshad Desai. 2017. "A Molecular View of Kinetochore Assembly and Function" Biology 6, no. 1: 5.

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