Next Article in Journal
A Laboratory Assessment of Factors That Affect Bacterial Adhesion to Contact Lenses
Next Article in Special Issue
Dancing to Another Tune—Adhesive Moonlighting Proteins in Bacteria
Previous Article in Journal
Elucidation of Nuclear and Organellar Genomes of Gossypium hirsutum: Furthering Studies of Species Evolution and Applications for Crop Improvement
Previous Article in Special Issue
Effect of Aminophenyl and Aminothiahexyl α-D-Glycosides of the Manno-, Gluco-, and Galacto-Series on Type 1 Fimbriae-Mediated Adhesion of Escherichia coli

The Role of the Bacterial Flagellum in Adhesion and Virulence

Division of General Microbiology, Department of Biosciences, University of Helsinki, P. O. Box 56, FI-00014 University of Helsinki, Finland
Author to whom correspondence should be addressed.
Biology 2013, 2(4), 1242-1267;
Received: 30 July 2013 / Revised: 27 September 2013 / Accepted: 30 September 2013 / Published: 25 October 2013
(This article belongs to the Special Issue Bacterial Adhesion)
The bacterial flagellum is a complex apparatus assembled of more than 20 different proteins. The flagellar basal body traverses the cell wall, whereas the curved hook connects the basal body to the whip-like flagellar filament that protrudes several µm from the bacterial cell. The flagellum has traditionally been regarded only as a motility organelle, but more recently it has become evident that flagella have a number of other biological functions. The major subunit, flagellin or FliC, of the flagellum plays a well-documented role in innate immunity and as a dominant antigen of the adaptive immune response. Importantly, flagella have also been reported to function as adhesins. Whole flagella have been indicated as significant in bacterial adhesion to and invasion into host cells. In various pathogens, e.g., Escherichia coli, Pseudomonas aeruginosa and Clostridium difficile, flagellin and/or the distally located flagellar cap protein have been reported to function as adhesins. Recently, FliC of Shiga-toxigenic E. coli was shown to be involved in cellular invasion via lipid rafts. Here, we examine the latest or most important findings regarding flagellar adhesive and invasive properties, especially focusing on the flagellum as a potential virulence factor. View Full-Text
Keywords: bacterial flagella; flagellin; FliD; adhesion; invasion bacterial flagella; flagellin; FliD; adhesion; invasion
Show Figures

Figure 1

MDPI and ACS Style

Haiko, J.; Westerlund-Wikström, B. The Role of the Bacterial Flagellum in Adhesion and Virulence. Biology 2013, 2, 1242-1267.

AMA Style

Haiko J, Westerlund-Wikström B. The Role of the Bacterial Flagellum in Adhesion and Virulence. Biology. 2013; 2(4):1242-1267.

Chicago/Turabian Style

Haiko, Johanna, and Benita Westerlund-Wikström. 2013. "The Role of the Bacterial Flagellum in Adhesion and Virulence" Biology 2, no. 4: 1242-1267.

Find Other Styles

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Back to TopTop