Friend or Foe: Protein Inhibitors of DNA Gyrase
Abstract
:Simple Summary
Abstract
1. Introduction
2. DNA Gyrase Functions as an Essential Type II Topoisomerase in Bacteria
3. Proteins Acting as Foes, Producing Damaging Gyrase Inhibition
3.1. ParE Toxin Proteins from ParDE Type II TA Systems
3.2. CcdB Toxin Proteins from CcdAB Type II TA Systems
3.3. TsbT Toxin Proteins from TsbAT Type II TA Systems
3.4. Microcin B17
4. Proteins Acting as Friends, Protecting Gyrase from Damaging Inhibition
4.1. Phage-Derived Peptides
4.2. FicT Toxins from FicTA Type II TA Systems
4.3. Pentapeptide Repeat Proteins
4.3.1. Qnr Proteins
4.3.2. MfpA Proteins
4.4. YacG
4.5. MurI
4.6. GyrI
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Ruan, S.; Tu, C.-H.; Bourne, C.R. Friend or Foe: Protein Inhibitors of DNA Gyrase. Biology 2024, 13, 84. https://doi.org/10.3390/biology13020084
Ruan S, Tu C-H, Bourne CR. Friend or Foe: Protein Inhibitors of DNA Gyrase. Biology. 2024; 13(2):84. https://doi.org/10.3390/biology13020084
Chicago/Turabian StyleRuan, Shengfeng, Chih-Han Tu, and Christina R. Bourne. 2024. "Friend or Foe: Protein Inhibitors of DNA Gyrase" Biology 13, no. 2: 84. https://doi.org/10.3390/biology13020084