Nuclear Lamins: Key Proteins for Embryonic Development
Institute of Experimental Medicine, Czech Academy of Sciences, Vídeňská 1083, 142 20 Prague, Czech Republic
Author to whom correspondence should be addressed.
Academic Editor: Yuki Hatanaka
Received: 30 December 2021
Revised: 21 January 2022
Accepted: 24 January 2022
Published: 27 January 2022
The biology of a multicellular organism is extremely complex, leaving behind a realm of compound yet systematic mechanisms still to be unraveled. The nucleus is a vital cellular organelle adapted to storing and regulating the hereditary genetic information. Dysregulation of the nucleus can have profound effects on the physiology and viability of cells. This becomes extremely significant in the context of development, where the whole organism arises from a single cell, the zygote. Therefore, even a mild aberration at this stage can have profound effects on the whole organism. However, studying the function of individual nuclear components at this point is exceptionally complicated because this phase is inherently under the control of maternal factors stored in the female germ cell, the egg. Here, we focus on the lamins, as essential nuclear components, and summarize the current knowledge of their role in development. Although scientists encounter challenges working with these miniscule yet key proteins, the demand to know more is increasing gradually due to the mutations caused in lamins leading to irreversible phenotypic conditions in humans.