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Review

Diagnostic and Prognostic Value of miRNAs after Coronary Artery Bypass Grafting: A Review

1
1st Chair and Department of Cardiology, Medical University of Warsaw, 02-091 Warsaw, Poland
2
Cardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-701 Poznan, Poland
3
1st Department of Cardiology, Medical University of Gdansk, 80-211 Gdansk, Poland
4
Department of Clinical Sciences, Maria Sklodowska-Curie Medical Academy, 03-411 Warsaw, Poland
*
Author to whom correspondence should be addressed.
E.B. and T.U. share the first authorship.
Academic Editor: Lemin Zheng
Biology 2021, 10(12), 1350; https://doi.org/10.3390/biology10121350
Received: 7 November 2021 / Revised: 9 December 2021 / Accepted: 16 December 2021 / Published: 19 December 2021
(This article belongs to the Special Issue The Etiology of Atherosclerosis/Coronary Artery Disease)
Coronary artery bypass graft (CABG) surgery is a procedure in which complex coronary arteries stenosis is treated by bypassing atherosclerotic lesions with venous or arterial grafts. CABG is associated with myocardial damage due to ischemia/reperfusion injury. In addition, postoperative complications, including perioperative myocardial infarction, atrial fibrillation and graft failure, remain important clinical challenges. So far, no reliable diagnostic and prognostic tools to predict outcomes after CABG surgery have been established. MiRNAs are noncoding, 21–24 nucleotide-long RNA particles, expressions of which alter during CABG surgery. Here, we summarize the potential clinical applicability of miRNAs as promising biomarkers to predict post-CABG procedure outcomes.
MiRNAs are noncoding, 21–24 nucleotide-long RNA particles that control over 60% of genes. MiRNAs affect gene expression through binding to the 3’-untranslated region of messenger RNA (mRNA), thus inhibiting mRNA translation or inducing mRNA degradation. MiRNAs have been associated with various cardiovascular diseases, including heart failure, hypertension, left ventricular hypertrophy, or ischemic heart disease. In addition, miRNA expression alters during coronary artery bypass grafting (CABG) surgery, which could be used to predict perioperative outcomes. CABG is an operation in which complex coronary arteries stenosis is treated by bypassing atherosclerotic lesions with venous or arterial grafts. Despite a very low perioperative mortality rate and excellent long-term survival, CABG is associated with postoperative complications, including reperfusion injury, graft failure, atrial fibrillation and perioperative myocardial infarction. So far, no reliable diagnostic and prognostic tools to predict prognosis after CABG have been developed. Changes in the perioperative miRNA expression levels could improve the diagnosis of post-CABG myocardial infarction and atrial fibrillation and could be used to stratify risk after CABG. Herein, we describe the expression changes of different subtypes of miRNAs during CABG and review the diagnostic and prognostic utility of miRNAs in patients undergoing CABG. View Full-Text
Keywords: miRNA; coronary artery bypass grafting; coronary artery disease; diagnosis; prognosis; biomarkers miRNA; coronary artery bypass grafting; coronary artery disease; diagnosis; prognosis; biomarkers
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MDPI and ACS Style

Błażejowska, E.; Urbanowicz, T.; Gąsecka, A.; Olasińska-Wiśniewska, A.; Jaguszewski, M.J.; Targoński, R.; Szarpak, Ł.; Filipiak, K.J.; Perek, B.; Jemielity, M. Diagnostic and Prognostic Value of miRNAs after Coronary Artery Bypass Grafting: A Review. Biology 2021, 10, 1350. https://doi.org/10.3390/biology10121350

AMA Style

Błażejowska E, Urbanowicz T, Gąsecka A, Olasińska-Wiśniewska A, Jaguszewski MJ, Targoński R, Szarpak Ł, Filipiak KJ, Perek B, Jemielity M. Diagnostic and Prognostic Value of miRNAs after Coronary Artery Bypass Grafting: A Review. Biology. 2021; 10(12):1350. https://doi.org/10.3390/biology10121350

Chicago/Turabian Style

Błażejowska, Ewelina, Tomasz Urbanowicz, Aleksandra Gąsecka, Anna Olasińska-Wiśniewska, Miłosz J. Jaguszewski, Radosław Targoński, Łukasz Szarpak, Krzysztof J. Filipiak, Bartłomiej Perek, and Marek Jemielity. 2021. "Diagnostic and Prognostic Value of miRNAs after Coronary Artery Bypass Grafting: A Review" Biology 10, no. 12: 1350. https://doi.org/10.3390/biology10121350

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