Disappearance of Temporal Collinearity in Vertebrates and Its Eventual Reappearance
Abstract
:Simple Summary
Abstract
1. Introduction
2. BM Formulation and Its Elastic Spring Approximation
3. Spatial and Temporal Collinearities in the Vertebrates
3.1. Paradigm of the HoxA Expressions in the Chick Limb Bud
- After the AER excision, HoxA13 is the first gene that rapidly switches off.
- Upon continuous exposure of the limb bud to an FGF soaked bead, HoxA13 is rescued after at least 6 h.
Exp II. | (a) → (b) → (c) → (d) | (direct step) |
(af) ← (b) ← (c) ← (d) | (reverse step) |
3.2. Paradigm of Gene Activation in the Mouse Embryo
(Exp. I) | (a) → (b) → (c) → (d) | (direct step) |
(a?) ← (b?) ← (c?) ← (d) | (reverse step) |
4. Discussion
- A.
- In the case of paradigm I the chip insertion operates in terra incognita and any prediction would be hazardous. Only Experiment can confirm a theory and fix the parameters involved in the data description. Note that an ideal Model is a ‘theory’ that predicts all experimental results in the realm of its implementation. Usually, a model can predict a limited set of results and all efforts aim at enlarging this domain by experimental trials. In the case of a microarray chip insertion the possible results one can anticipate are the following:
- no response at all—no difference observed with or without pulling forces.
- a partial restoration of HoxA13 expression (b?, c?)
- a full rescue of HoxA13 (a?)
- B.
- A very important consequence of the above TC disappearance is its connection to TC loss as an evolutionary instrument applied to many animal phyla where TC is absent as, for instance, in Drosophila [8].
- C.
- TC disappearance is a very striking event. A less striking effect is TC violation as observed by M. Kondo et al. in Xenopus leavis [16].
5. Conclusions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
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Papageorgiou, S. Disappearance of Temporal Collinearity in Vertebrates and Its Eventual Reappearance. Biology 2021, 10, 1018. https://doi.org/10.3390/biology10101018
Papageorgiou S. Disappearance of Temporal Collinearity in Vertebrates and Its Eventual Reappearance. Biology. 2021; 10(10):1018. https://doi.org/10.3390/biology10101018
Chicago/Turabian StylePapageorgiou, Spyros. 2021. "Disappearance of Temporal Collinearity in Vertebrates and Its Eventual Reappearance" Biology 10, no. 10: 1018. https://doi.org/10.3390/biology10101018
APA StylePapageorgiou, S. (2021). Disappearance of Temporal Collinearity in Vertebrates and Its Eventual Reappearance. Biology, 10(10), 1018. https://doi.org/10.3390/biology10101018