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Fibers 2017, 5(1), 13;

The Design of Temperature-Responsive Nanofiber Meshes for Cell Storage Applications

International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), Tsukuba 305-0044, Japan
Graduate School of Pure and Applied Sciences, University of Tsukuba, Tsukuba 305-8571, Japan
Department of Material Science and Technology, Graduate School of Tokyo, University of Science, Tokyo 278-8510, Japan
Author to whom correspondence should be addressed.
Academic Editors: Martin J. D. Clift and Stephen C. Bondy
Received: 26 January 2017 / Revised: 10 March 2017 / Accepted: 15 March 2017 / Published: 21 March 2017
(This article belongs to the Special Issue Medical Application of Nanofibers)
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Here we report on the fabrication and characterization of temperature-responsive electrospun nanofiber meshes using N-isopropylacrylamide homopolymer (PNIPAAm). The effect of molecular weight on fiber formation and their thermoresponsive shrinking/dissolution behaviors were investigated. The PNIPAAm fiber meshes showed much faster temperature-dependent shrinking or dissolution than that of its corresponding film due to its unique fibrous structure. By utilizing these quick and dynamic shrinking/dissolution properties, we successfully demonstrated the temperature-modulated “on-off” capture/release systems for macroscopic or mesoscopic-scale objects. Finally, we explored the potential application of PNIPAAm meshes for cell storage. View Full-Text
Keywords: temperature-responsive; nanofibers; N-isopropylacrylamide; cryopreservation temperature-responsive; nanofibers; N-isopropylacrylamide; cryopreservation

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Maeda, T.; Kim, Y.-J.; Aoyagi, T.; Ebara, M. The Design of Temperature-Responsive Nanofiber Meshes for Cell Storage Applications. Fibers 2017, 5, 13.

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