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Open AccessCommunication

Differentiating Generic versus Branded Pharmaceutical Tablets Using Ultra-High-Resolution Optical Coherence Tomography

1
Department of Electrical Engineering and Electronics, University of Liverpool, Liverpool L69 3GJ, UK
2
Department of Eye and Vision Science, University of Liverpool, Liverpool L7 8TX, UK
3
Department of Engineering, Lancaster University, Lancaster LA1 4YW, UK
*
Author to whom correspondence should be addressed.
Coatings 2019, 9(5), 326; https://doi.org/10.3390/coatings9050326
Received: 7 April 2019 / Revised: 14 May 2019 / Accepted: 15 May 2019 / Published: 17 May 2019
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Abstract

Optical coherence tomography (OCT) has recently been demonstrated as a powerful tool to image through pharmaceutical film coatings. Majority of the existing systems can, however, resolve film coatings for thickness greater than 10 µm. Here we report on an ultra-high-resolution (UHR) OCT system, with 1 µm axial and 1.6 µm lateral resolutions, which can resolve thin coatings at approximately 4 µm. We further demonstrate a novel application of the system for differentiating generic and branded suppliers of paracetamol tablets. View Full-Text
Keywords: pharmaceutical film coating; thin coating; 500-mg paracetamol tablet; GSK Panadol; generic paracetamol; optical coherence tomography; image segmentation; differentiation pharmaceutical film coating; thin coating; 500-mg paracetamol tablet; GSK Panadol; generic paracetamol; optical coherence tomography; image segmentation; differentiation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Zhang, Z.; Williams, B.; Zheng, Y.; Lin, H.; Shen, Y. Differentiating Generic versus Branded Pharmaceutical Tablets Using Ultra-High-Resolution Optical Coherence Tomography. Coatings 2019, 9, 326.

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