Differentiating Generic versus Branded Pharmaceutical Tablets Using Ultra-High-Resolution Optical Coherence Tomography
1
Department of Electrical Engineering and Electronics, University of Liverpool, Liverpool L69 3GJ, UK
2
Department of Eye and Vision Science, University of Liverpool, Liverpool L7 8TX, UK
3
Department of Engineering, Lancaster University, Lancaster LA1 4YW, UK
*
Author to whom correspondence should be addressed.
Coatings 2019, 9(5), 326; https://doi.org/10.3390/coatings9050326
Received: 7 April 2019 / Revised: 14 May 2019 / Accepted: 15 May 2019 / Published: 17 May 2019
Abstract
Optical coherence tomography (OCT) has recently been demonstrated as a powerful tool to image through pharmaceutical film coatings. Majority of the existing systems can, however, resolve film coatings for thickness greater than 10 µm. Here we report on an ultra-high-resolution (UHR) OCT system, with 1 µm axial and 1.6 µm lateral resolutions, which can resolve thin coatings at approximately 4 µm. We further demonstrate a novel application of the system for differentiating generic and branded suppliers of paracetamol tablets. View Full-TextKeywords:
pharmaceutical film coating; thin coating; 500-mg paracetamol tablet; GSK Panadol; generic paracetamol; optical coherence tomography; image segmentation; differentiation
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Zhang, Z.; Williams, B.; Zheng, Y.; Lin, H.; Shen, Y. Differentiating Generic versus Branded Pharmaceutical Tablets Using Ultra-High-Resolution Optical Coherence Tomography. Coatings 2019, 9, 326.
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