Differentiating Generic versus Branded Pharmaceutical Tablets Using Ultra-High-Resolution Optical Coherence Tomography
1
Department of Electrical Engineering and Electronics, University of Liverpool, Liverpool L69 3GJ, UK
2
Department of Eye and Vision Science, University of Liverpool, Liverpool L7 8TX, UK
3
Department of Engineering, Lancaster University, Lancaster LA1 4YW, UK
*
Author to whom correspondence should be addressed.
Coatings 2019, 9(5), 326; https://doi.org/10.3390/coatings9050326
Received: 7 April 2019
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Revised: 14 May 2019
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Accepted: 15 May 2019
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Published: 17 May 2019
Optical coherence tomography (OCT) has recently been demonstrated as a powerful tool to image through pharmaceutical film coatings. Majority of the existing systems can, however, resolve film coatings for thickness greater than 10 µm. Here we report on an ultra-high-resolution (UHR) OCT system, with 1 µm axial and 1.6 µm lateral resolutions, which can resolve thin coatings at approximately 4 µm. We further demonstrate a novel application of the system for differentiating generic and branded suppliers of paracetamol tablets.
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Keywords:
pharmaceutical film coating; thin coating; 500-mg paracetamol tablet; GSK Panadol; generic paracetamol; optical coherence tomography; image segmentation; differentiation
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MDPI and ACS Style
Zhang, Z.; Williams, B.; Zheng, Y.; Lin, H.; Shen, Y. Differentiating Generic versus Branded Pharmaceutical Tablets Using Ultra-High-Resolution Optical Coherence Tomography. Coatings 2019, 9, 326. https://doi.org/10.3390/coatings9050326
AMA Style
Zhang Z, Williams B, Zheng Y, Lin H, Shen Y. Differentiating Generic versus Branded Pharmaceutical Tablets Using Ultra-High-Resolution Optical Coherence Tomography. Coatings. 2019; 9(5):326. https://doi.org/10.3390/coatings9050326
Chicago/Turabian StyleZhang, Zijian, Bryan Williams, Yalin Zheng, Hungyen Lin, and Yaochun Shen. 2019. "Differentiating Generic versus Branded Pharmaceutical Tablets Using Ultra-High-Resolution Optical Coherence Tomography" Coatings 9, no. 5: 326. https://doi.org/10.3390/coatings9050326
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