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Coatings 2019, 9(2), 141; https://doi.org/10.3390/coatings9020141

Effects of Strontium-Hydroxyapatite Mediated Active Compounds from Hippocampus Kuda Bleeler (HKB) on Osteogenesis

1
School of Chemistry and Environment, Guangdong Ocean University, Zhanjiang 524088, China
2
Shenzhen Institute of Guangdong Ocean University, Shenzhen 518108, China
3
College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China
*
Authors to whom correspondence should be addressed.
Received: 23 January 2019 / Revised: 15 February 2019 / Accepted: 18 February 2019 / Published: 21 February 2019
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Abstract

Porous hydroxyapatite as a drug carrier is very popular and has many clinical applications. However, traditional hydroxyapatite materials have limited osteogenic capacity. Therefore, the development of a new hydroxyapatite drug delivery system is essential for bone tissue engineering. In this study, the metal element Sr was used to replace Ca, and the SrHA microspheres were successfully prepared by hydrothermal reaction. Scanning electron microscopy (SEM), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS) were used to characterize SrHA (strontium-doped hydroxyapatite) microspheres obtained from hydrothermal reaction conditions. In addition, the drug utility was enhanced by loading the marine active compound 1-(5-bromo-2-hydroxy-4-methoxyphenyl)-ethanone (HKB). Furthermore, after co-culture with preosteoblasts, experiments indicated that HKB/SrHA composite microspheres had a more significant effect on the proliferation and differentiation of cells compared to pure SrHA. These HKB/SrHA composite microspheres may be applied to the drug delivery system of bone tissue repair. View Full-Text
Keywords: hydroxyapatite; strontium; hippocampus kuda bleeler; MC3T3-E1 hydroxyapatite; strontium; hippocampus kuda bleeler; MC3T3-E1
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Li, C.; Yuan, Q.; He, L.; Qian, Z.-J.; Zhou, C.; Hong, P. Effects of Strontium-Hydroxyapatite Mediated Active Compounds from Hippocampus Kuda Bleeler (HKB) on Osteogenesis. Coatings 2019, 9, 141.

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