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Pulsed Laser Deposited Biocompatible Lithium-Doped Hydroxyapatite Coatings with Antimicrobial Activity

1
National Institute for Lasers, Plasma and Radiation Physics, 077125 Magurele, Romania
2
Department of Microbiology, Faculty of Biology, University of Bucharest, 060101 Bucharest, Romania
3
Earth, Environmental and Life Sciences Division, Research Institute of the University of Bucharest (ICUB), 060101 Bucharest, Romania
4
“Stefan S. Nicolau” Institute of Virology, 030304 Bucharest, Romania
5
“Ilie Murgulescu” Institute of Physical Chemistry, Romanian Academy, 060021 Bucharest, Romania
6
Center for Advanced Laser Technologies (CETAL), National Institute for Lasers, Plasma and Radiation Physics, 077125 Magurele, Romania
*
Authors to whom correspondence should be addressed.
Coatings 2019, 9(1), 54; https://doi.org/10.3390/coatings9010054
Received: 5 December 2018 / Revised: 14 January 2019 / Accepted: 16 January 2019 / Published: 17 January 2019
(This article belongs to the Special Issue Ion-Substituted Calcium Phosphates Coatings)
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Abstract

Simple and lithium-doped biological-origin hydroxyapatite layers were synthesized by Pulsed Laser Deposition technique on medical grade Ti substrates. Cytotoxic effects of lithium addition and the biocompatibility of obtained coatings were assessed using three cell lines of human origin (new initiated dermal fibroblasts, immortalized keratinocytes HaCaT, and MG-63 osteosarcoma). Antimicrobial properties of obtained coatings were assessed on two strains (i.e., Staphylococcus aureus and Candida albicans), belonging to species representative for the etiology of medical devices biofilm-associated infections. Our findings suggest that synthesized lithium-doped coatings exhibited low cytotoxicity on human osteosarcoma and skin cells and therefore, an excellent biocompatibility, correlated with a long-lasting anti-staphylococcal and -fungal biofilm activity. Along with low fabrication costs generated by sustainable resources, these biological-derived materials demonstrate their promising potential for future prospective solutions—viable alternatives to commercially available biomimetic HA implants—for the fabrication of a new generation of implant coatings. View Full-Text
Keywords: lithium-doped hydroxyapatite coatings; renewable resources for implant coatings; pulsed laser deposition; biocompatibility; inhibition of microbial biofilms development lithium-doped hydroxyapatite coatings; renewable resources for implant coatings; pulsed laser deposition; biocompatibility; inhibition of microbial biofilms development
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Duta, L.; Chifiriuc, M.C.; Popescu-Pelin, G.; Bleotu, C.; Gradisteanu, G.P.; Anastasescu, M.; Achim, A.; Popescu, A. Pulsed Laser Deposited Biocompatible Lithium-Doped Hydroxyapatite Coatings with Antimicrobial Activity. Coatings 2019, 9, 54.

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