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Coatings 2018, 8(6), 203; https://doi.org/10.3390/coatings8060203

Osteogenesis and Antibacterial Activity of Graphene Oxide and Dexamethasone Coatings on Porous Polyetheretherketone via Polydopamine-Assisted Chemistry

1
School of Materials Science and Engineering, Sichuan University, Chengdu 610065, China
2
School of Chemical Engineering, Sichuan University, Chengdu 610065, China
3
Department of Mechanical Engineering, The University of Hong Kong, Pokfulam, Hong Kong 999077, China
*
Authors to whom correspondence should be addressed.
Received: 18 April 2018 / Revised: 7 May 2018 / Accepted: 24 May 2018 / Published: 28 May 2018
(This article belongs to the Special Issue Advanced Bioadhesive and Bioabhesive Coatings)
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Abstract

Endowing implants with antibacterial ability and osteogenic ability plays important roles in preventing post-operative bacterial contamination and facilitating integration between implants and osseous tissue, consequently reducing implant failure rates. In this study, we develop a facile and versatile strategy with dopamine as an auxiliary for construction of dexamethasone (Dex)/liposome porous coatings. In detail, the surfaces of sulfonated polyetheretherketone (SP) plates are coated with polydopamine firstly and then modified with graphene oxide (GO) and dexamethasone (Dex)-loaded liposome, which is verified by contact angle, X-ray photoelectron spectroscopy (XPS), attenuated total reflection infrared (ATR), and Raman spectra. The results of our study suggest that the GO and Dex are successfully coated on the samples’ surfaces. In vitro cell attachment, growth, differentiation, and apatite deposition tests all illustrate that the substrate coated with GO and Dex can significantly accelerate the proliferation and osteogenic differentiation of MC3T3 cells compared with the pristine sulfonated polyetheretherketone (PEEK). Additionally, it exhibits acceptable antibacterial activity against E. coli and S. aureus in vitro. Altogether, our results demonstrate that the modified GO- and Dex-loaded substrates are endowed with impressive biocompatibility and certain antibacterial qualities, making it possible for future application as a perspective implant material. View Full-Text
Keywords: dexamethasone; liposome; graphene oxide; cytocompatibility; antibacterial dexamethasone; liposome; graphene oxide; cytocompatibility; antibacterial
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Ouyang, L.; Qi, M.; Wang, S.; Tu, S.; Li, B.; Deng, Y.; Yang, W. Osteogenesis and Antibacterial Activity of Graphene Oxide and Dexamethasone Coatings on Porous Polyetheretherketone via Polydopamine-Assisted Chemistry. Coatings 2018, 8, 203.

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