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Open AccessArticle

Polymerization of PEDOT/PSS/Chitosan-Coated Electrodes for Electrochemical Bio-Sensing

School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
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Coatings 2017, 7(7), 96; https://doi.org/10.3390/coatings7070096
Received: 15 May 2017 / Revised: 27 June 2017 / Accepted: 4 July 2017 / Published: 6 July 2017
(This article belongs to the Special Issue Novel Thin Film Materials for Biomedical Application)
Poly(3,4-ethylenedioxythiophene) (PEDOT) doped with poly (styrene sulfonate) (PSS) has a variety of chemical and biomedical applications. Additionally, chitosan has been extensively used in industrial and medical fields. However, whether chitosan could be incorporated into conducting polymers of PEDOT/PSS is not clear. In this study, the PEDOT/PSS/chitosan coatings were electrochemically polymerized on the surface of 0.5 mm platinum (Pt) electrodes and the properties of electrochemical cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) of the PEDOT/PSS/chitosan-coated electrodes were investigated. Furthermore, PEDOT/PSS/chitosan-coated electrodes used for electrochemical bio-sensing, using dexamethasone (Dex) as a model bio-sensing material, were examined. The results demonstrated that PEDOT/PSS/chitosan-coated electrodes were stable in phosphate-buffered saline (PBS) solution. The electrochemical CV curve areas, reflecting the charge delivery capacity, and the EIS of the PEDOT/PSS/chitosan-coated electrodes were sensitive to Dex, and the good linearity can be obtained between CV curve areas, the EIS and the concentration of Dex. In addition, electrochemical sensitivity of the PEDOT/PSS/chitosan-coated electrodes to Dex was much higher than ultraviolet (UV) spectroscopy detection. All these results revealed that the PEDOT/PSS/chitosan-coated electrodes can be electrochemical polymerized and used for electrochemical bio-sensing. View Full-Text
Keywords: poly(3,4-ethylenedioxythiophene) (PEDOT); chitosan; electrochemical polymerization; bio-sensing; dexamethasone poly(3,4-ethylenedioxythiophene) (PEDOT); chitosan; electrochemical polymerization; bio-sensing; dexamethasone
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Sui, L.; Zhang, B.; Wang, J.; Cai, A. Polymerization of PEDOT/PSS/Chitosan-Coated Electrodes for Electrochemical Bio-Sensing. Coatings 2017, 7, 96.

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