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Article

Silk Fibroin-Based Hybrid Nanostructured Coatings for Titanium Implantable Surfaces Modification

Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 313 Splaiul Independentei, 060042 Bucharest, Romania
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Coatings 2020, 10(6), 518; https://doi.org/10.3390/coatings10060518
Received: 27 March 2020 / Revised: 7 May 2020 / Accepted: 26 May 2020 / Published: 28 May 2020
(This article belongs to the Special Issue Recent Advances in Bioactive Coatings)
This study proposes the development of new architectures that combine nanostructured titanium surface and biodegradable polymers as a promising approach to achieve a better performance after bioactive agent incorporation. The silk fibroin protein that was extracted from silkworm Bombyx mori cocoons is important due to the remarkable characteristics, such as biocompatibility, good mechanical properties, adjustable degradation and drug stabilizing capabilities. The titanium substrate was firstly nanostructurated with TiO2 nanotubes and then coated with silk fibroin using electrospinning and electrochemical deposition. The deposited silk film ability to become a bioactive implant coating with antibacterial properties after the encapsulation of the active agents such as CeO2 was investigated. Important features of the new implant coating were analysed: surface properties, electrochemical stability in physiological simulated electrolytes, and antibacterial action against Escherichia coli. The obtained results indicate that silk fibroin bioactive layers are a potential candidate for regenerative medicine. View Full-Text
Keywords: titanium; TiO2 nanotubes; silk fibroin; CeO2 nanoparticles; antibacterial effect titanium; TiO2 nanotubes; silk fibroin; CeO2 nanoparticles; antibacterial effect
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MDPI and ACS Style

Popescu, S.; Zarif, M.-E.; Dumitriu, C.; Ungureanu, C.; Pirvu, C. Silk Fibroin-Based Hybrid Nanostructured Coatings for Titanium Implantable Surfaces Modification. Coatings 2020, 10, 518. https://doi.org/10.3390/coatings10060518

AMA Style

Popescu S, Zarif M-E, Dumitriu C, Ungureanu C, Pirvu C. Silk Fibroin-Based Hybrid Nanostructured Coatings for Titanium Implantable Surfaces Modification. Coatings. 2020; 10(6):518. https://doi.org/10.3390/coatings10060518

Chicago/Turabian Style

Popescu, Simona, Maria-Elena Zarif, Cristina Dumitriu, Camelia Ungureanu, and Cristian Pirvu. 2020. "Silk Fibroin-Based Hybrid Nanostructured Coatings for Titanium Implantable Surfaces Modification" Coatings 10, no. 6: 518. https://doi.org/10.3390/coatings10060518

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