Availability and Use of Therapeutic Interchange Policies in Managing Antimicrobial Shortages among South African Public Sector Hospitals; Findings and Implications
1
Division of Public Health Pharmacy and Management, School of Pharmacy, Sefako Makgatho Health Sciences University, Ga-Rankuwa, Pretoria 0208, South Africa
2
Strathclyde Institute of Pharmacy and Biomedical Sciences, Strathclyde University, Glasgow G4 ORE, UK
3
Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institute, Karolinska University Hospital Huddinge, SE-141 86 Stockholm, Sweden
4
Health Economics Centre, Liverpool University Management School, Chatham Street, Liverpool L69 7ZH, UK
*
Author to whom correspondence should be addressed.
Antibiotics 2020, 9(1), 4; https://doi.org/10.3390/antibiotics9010004
Submission received: 29 October 2019
/
Revised: 22 November 2019
/
Accepted: 5 December 2019
/
Published: 20 December 2019
Abstract
:Background: Therapeutic interchange policies in hospitals are useful in dealing with antimicrobial shortages and minimising resistance rates. The extent of antimicrobial shortages and availability of therapeutic interchange policies is unknown among public sector hospitals in South Africa. This study aimed to ascertain the extent of and rationale for dealing with antimicrobial shortages, describe policies or guidelines available, and the role of pharmacists in the process. Methods: A quantitative and descriptive study was conducted with a target population of 403 public sector hospitals. Data were collected from hospital pharmacists using an electronic questionnaire via SurveyMonkeyTM. Results: The response rate was 33.5% and most (83.3%) hospitals had experienced shortages in the previous six months. Antimicrobials commonly reported as out of stock included cloxacillin (54.3%), benzathine benzylpenicillin (54.2%), and erythromycin (39.6%). Reasons for shortages included pharmaceutical companies with supply constraints (85.3%) and an inefficient supply system. Only 42.4% had therapeutic interchange policies, and 88.9% contacted the prescriber, when present, for substitution. Conclusions: Antimicrobial shortages are prevalent in South African public sector hospitals with the most affected being penicillins and cephalosporins. Therapeutic interchange policies are not available at most hospitals. Effective strategies are required to improve communication between pharmacists and prescribers to ensure that safe, appropriate, and therapeutically equivalent alternatives are available.
1. Background
Sub-Saharan African countries including South Africa have the highest burden of infectious diseases worldwide, enhanced by high prevalence rates of HIV, malaria, and tuberculosis [1,2,3], with antimicrobials crucial to reducing the burden of communicable diseases [4]. On one hand, there are concerns regarding the inappropriate use of antibiotics leading to increasing rates of antimicrobial resistance (AMR) limiting therapeutic options, which have resulted in the introduction of antimicrobial stewardship programmes (AMSPs) across countries acknowledging though the challenges [5,6,7,8]. However, shortages of antimicrobials are also a challenge in Africa [9,10,11], potentially resulting in the use of antibiotics that place patients at a greater risk of Clostridium difficile infections as well as increased AMR [12,13].
The medicine shortage situation in South Africa is also a concern receiving media attention [14,15,16]. As a result, national monitoring programmes have been put in place in South Africa with the support of the National Department of Health (NDoH). These include improved supply management programmes as well as the ‘Stop Stockouts’ initiative, which is a consortium of civil society organisations [17,18]. Despite these initiatives, shortages are still being experienced in some provinces in South Africa [16,18,19]. Shortages of antimicrobials are regarded as a public health emergency due to the necessity to expedite treatment in the case of an infection and because escalating AMR rates limit therapeutic options for many pathogens [20,21].
Where shortages of antimicrobials exist, therapeutic interchange policies can potentially help ensure that substitution is not haphazard or inappropriate [22]. Pharmacists can play a crucial role in the development and implementation of therapeutic interchange policies in hospitals combined with other key stakeholder groups, building on activities within Pharmacy and Therapeutic Committees (PTCs) as well as AMSPs [8,23,24]. Whilst the effective functioning of PTCs is improving in South Africa and AMSPs are evolving [23,24], there are concerns regarding the extent of therapeutic interchange policies among public sector hospitals in South Africa, especially regarding antimicrobials. The NDoH published a policy in 2017 to provide guidance for the placement of medicines in classes to support therapeutic interchange programmes where pertinent [25]. However, the policy only provides guidelines on required procedures when switching a patient from one medicine to another within the same therapeutic class, but not on therapeutic interchanges where this is not possible such as antimicrobials. As a result, there is a need to build on this initiative.
Consequently, this study sought to identify and describe the current therapeutic interchange policies in the event of drug shortages among public sector hospitals in South Africa following the NDoH initiative. Antimicrobials were chosen in light of the extent of infectious diseases in sub-Saharan Africa, with public sector hospitals chosen as they offer health services to approximately 80% of the population in South Africa [17]. The findings can be used to guide future policies in South Africa as well as possibly wider.
2. Materials and Methods
We used a descriptive survey design and a quantitative research approach. All public sector hospitals including district, regional, and tertiary/academic hospitals (n = 403) in the nine provinces of South Africa were targeted for participation. One pharmacist from each hospital, in most instances the ‘Drug Controller’, ‘Procurement Pharmacist’, or ‘Pharmacy Manager’, were purposively selected to complete the questionnaire. In hospitals where none of these were available, a qualified pharmacist or community service pharmacist was requested to participate.
Data were collected from March to July 2018. The survey was conducted using a 23 item electronic questionnaire administered via SurveyMonkey™. A questionnaire link was sent via email or fax to pharmacists who agreed to take part with anonymous completion. The questionnaire was compiled, based on the published literature [11,22,26,27,28,29], after which an expert review followed. It was divided into three sections: demographics, antimicrobial shortages, and therapeutic interchange. The questionnaire also included information on current PTC- and AMSP activities in the hospitals.
Data were exported from SurveyMonkey™ to Microsoft Office Excel™ and cleaned prior to analysis using the Statistical Package for the Social Sciences (SPSS) version 25. Open-ended responses were typed into MS Excel™, and relevant categories were created to allow for the counting of responses. Descriptive statistics were used to summarise data using means with standard deviation (SD) and frequency counts with percentages. Antibiotics were classified by Anatomical Therapeutic Chemical (ATC) class [30]. All analyses were conducted at a 95% confidence interval.
Ethical clearance for the study was granted by the Sefako Makgatho University Research Ethics Committee (SMUREC/P/269/2017:PG), and permission was obtained from the NDoH.
3. Results
3.1. Response Rate and Demographic Details
Of the 403 hospitals, approval to conduct the study was received for 346 hospitals (Table 1). Of these 346 hospitals, 81 facilities could not be reached using email addresses and 11 declined to participate. A total of 85 responses were finally received, giving a response rate of 33.5% (Table 1).
More than half of the respondents were female (63.5%), with a mean age of 38 years (SD: 9.8) (Table 2). The mean number of years in practice was 9.3 years (SD: 7.42), with 62.2% having less than 10-years of experience. Almost half (48.2%) were pharmacy managers, with most working at district hospitals (Table 2).
3.2. Antimicrobial Shortages
The majority of respondents (83.3%) indicated they had experienced antimicrobial shortages at their institutions in the previous six months. Most shortages were for antibiotics, particularly penicillins, with a limited number in the antiviral (acyclovir) and antifungal (amphotericin B, clotrimazole) classes (Table 3). Most of the shortages exceeded 40 days.
3.3. Reasons for Antimicrobial Shortages
The majority of respondents (85.3%) stated that supply problems with pharmaceutical companies were the main contributor to shortages (Table 4). The impact included dispensing later generation (84.4%) and more expensive alternatives (64.9%). The procedures for reporting medicine shortages included sending weekly reports to the central/provincial office or the district pharmacist (Table 4).
A considerable number of facilities had active PTCs (86.9%) and Antimicrobial Stewardship Committees (AMSCs) (70.2%). Most respondents were members of PTCs (77.4%) and AMSCs (51.2%).
3.4. Therapeutic Interchange Policies
Less than half (42.4%) of respondents stated they had therapeutic interchange policies in place in their hospitals, of whom 30.2% reported that these were documented (Table 5). Pre-consultation with the prescriber before substitution was a requirement in 95.2% of the facilities. The extent of policies, their development, actions taken by the pharmacist, and substitution procedures followed in the absence of policies, are documented in Table 5.
3.5. Role of the Pharmacist in Therapeutic Interchange
More than a third of the respondents (37.1%) said the pharmacists should communicate with prescribers regarding suitable therapeutic options when there are shortages as well as facilitate the development of therapeutic interchange policies (22.9%) to improve subsequent care (Table 6).
4. Discussion
We believe this is the first comprehensive study among public sector hospitals in South Africa to review the current situation regarding therapeutic interchange policies following NDoH guidance [25]. The response rate of 33.5%, despite sending up to 12 reminders, which was similar to one study conducted in the US (40%) [31]; however, it was higher than studies in Europe and another study in the US with response rates of 22% and 13%, respectively [29,32]. Pharmacy managers provided the highest number of responses (Table 2), similar to a study conducted in the US [33].
The majority of participating hospitals had experienced antimicrobial shortages in the preceding six months, similar to studies conducted in Australia, Europe, and the US [32,34]. Shortages were either reported to the pharmacy manager, the PTC, hospital management, or the provincial office by the pharmacists, similar to the findings in a US survey [31]. It is important that shortages are reported to the relevant authorities and immediately communicated to prescribers so that pertinent strategies can be urgently identified and implemented.
The majority of shortages reported were for penicillins, followed by cephalosporins (Table 3), similar to findings in the US, Europe, and Australia [10,11,32,34]. Most of the shortages lasted more than 40 days. This is a concern, although shortages between one week and over a year have been seen in Europe and the US [11,32]. Pharmaceutical companies with supply or capacity problems, an inefficient supply system, poor stock control and financial resources were the main reasons for shortages (Table 4). However, new initiatives have recently been introduced in South Africa to help improve stock control, and we will be investigating their impact in future studies [17].
Most pharmacists reported that they had resorted to dispensing later generation antimicrobials or more expensive alternatives when faced with shortages, similar to studies in Europe and Australia [32,34]. This though may potentially hinder AMS efforts as shortages of one antimicrobial can result in shortages of others used for substitution, potentially negatively impacting on patient outcomes [35].
Encouragingly, the majority of the respondents said that their hospitals had active PTCs and AMSCs. This is welcomed, especially as one of the aims and objectives of the South African National Drug Policy is to establish and strengthen PTCs in all hospitals [23,24,36]. However, of concern was that less than half of the respondents (42.4%) stated their hospitals had therapeutic interchange policies. Of these, only nine had policies or substitution guidelines from their institutional PTCs. This is consistent though with a recent survey conducted among public sector hospitals in South Africa that found that the development and implementation of guidelines other than the formulary is not a primary function of hospital PTCs [23]. In addition, only 33% of participants referred to the NDoH notice to develop their therapeutic interchange policies. This needs to be addressed as it is difficult to adhere to and revise guidelines that are not documented and actively communicated.
Half of the respondents stated that therapeutic interchange policies were the responsibility of PTCs, with PTCs generally considered the most ideal setting for such programmes, which is encouraging as they can ensure that any guidelines are based on scientific evidence and any national Essential Medicine List [17,37,38,39]. Several actions were reported as part of the pharmacist’s practice during substitution (Table 5) including communication with other health professionals and providing information on available alternatives. This is also important as decisions should be made in collaboration with all key stakeholders [35]. Encouragingly, very few respondents stated they substituted without consulting the prescriber, with 92.5% stating that pre-consultation with the prescriber was a requirement before substitution in their hospital. This is important for building trust among teams. The opposite was observed in the US where 67% of institutions performed automatic substitutions preapproved by PTCs [31]. More than a quarter of respondents in our study stated that they sent the patient back to the prescriber when a prescribed medicine was unavailable, implying that shortages were not always communicated in a timely manner. This needs to be addressed as it is important that pharmacists actively communicate with prescribers and help jointly develop therapeutic interchange policies to optimize patient care and minimize patient inconvenience [22,40].
Encouragingly, more than half of the respondents undertook keeping a record of the interchange. Additionally, it was encouraging that respondents emphasised the importance of communication with prescribers and active participation in research related to substitution decisions as well as facilitation of therapeutic interchange policy development (Table 6) in going forward. We will be building on this in future studies. Finally, some pharmacists have highlighted the importance of effective communication channels between the National/Provincial Department of Health and health facilities. This is consistent with the WHO’s recommendation to scale up systems at a national level that collect and monitor data on medicines availability for better evidence-based policy making [41].
The study had several limitations. We acknowledge there was a relatively low response rate, more than half of the respondents had less than 10-years of experience, and the responses were self-reported. It is also likely that not all shortages were accounted for due to recall bias. Furthermore, there appeared to be differences in the interpretation of therapeutic interchange policies among the pharmacists taking part. Despite these limitations, we believe that the study was robust, providing an insight into the current status of antimicrobial shortages and interchange policies among public sector hospitals in South Africa.
5. Conclusions and Recommendations
From our findings, it is evident that most South African public sector hospitals experience antimicrobial shortages, particularly for penicillins and cephalosporins. These shortages may last in excess of 40 days, which can affect service delivery, AMS efforts, and patient outcomes. Of concern is that the practice of therapeutic interchange is currently not that common among public sector hospitals in South Africa and not entirely understood by pharmacists working in these hospitals. Efforts should be made to train PTC members on how to develop evidence-based policies to manage medicine shortages in their institutions, with pharmacists playing a key role based on their training. There should also be increased communication with depots and ordering early, considering depot lead times.
We also believe that based on our findings, clear processes for the effective communication of anticipated and ongoing shortages of medicines, including antimicrobials should be established among all public sector hospitals. These hospitals should design and implement measures to ameliorate weaknesses in the inventory control process as well as minimise disruptions in medicine supply, building on current initiatives in South Africa. These measures should prioritise antimicrobial preservation given concerns with rising AMR rates in South Africa.
Furthermore, therapeutic interchange policies should be considered for implementation at various levels of care as they take into consideration the spectrum of activity, cost, and associated adverse drug reactions of different antimicrobials, which can be part of AMSPs. This will be followed-up in the future. We hope our findings are of interest to other low to medium income countries experiencing challenges with medicine shortages, especially antimicrobials in hospitals.
Author Contributions
A.K.C., M.M., and J.C.M. conceptualised and designed the study. A.K.C. developed the data collection tool with contribution from M.M. and J.C.M. A.K.C. collected and analysed the data. All authors participated in the interpretation of the data. A.K.C. and B.G. wrote the first draft of the manuscript. All authors have read and agreed to the published version of the manuscript.
Funding
A.K.C. conducted the study as part of a master’s degree qualification and received student tuition funding from the National Research Foundation. The study was self-funded, apart from the license for the use of SurveyMonkey™, which was funded through a National Research Foundation grant.
Acknowledgments
The authors wish to acknowledge the respective Provincial Departments of Health and hospital authorities for granting permission to conduct the study. We would like to express our gratitude to all of the public sector hospital pharmacists who responded to the survey for their time and valuable responses.
Conflicts of Interest
The authors declare that they have no conflicts of interest.
Compliance with Ethical Standards
Ethical clearance for the study was granted by the Sefako Makgatho University Research Ethics Committee (SMUREC/P/269/2017:PG), and permission was obtained from the NDoH. The electronic questionnaire included a consent statement and the clearance number; completion of the questionnaire by participants was regarded as consent.
Data Availability
The datasets during and/or analysed during the current study are available from the corresponding author on reasonable request.
List of Abbreviations
| Abbreviation | Meaning |
| AMR AMS | Antimicrobial Resistance Antimicrobial Stewardship |
| AMSCs AMSPs | Antimicrobial Stewardship Committees Antimicrobial Stewardship Programmes |
| ATC | Anatomical Therapeutic Chemical Classification |
| CEO | Chief Executive Officer |
| HIV | Human Immunodeficiency Virus |
| MS | Microsoft Office |
| NDoH | National Department of Health |
| PTC | Pharmacy and Therapeutics Committee |
| SD | Standard Deviation |
| SMUREC | Sefako Makgatho University Research Ethics Committee |
| SOP | Standard Operating Procedures |
| SPSS | Statistical Package for the Social Sciences |
| WHO | World Health Organization |
References
- Wanyiri, J.W.; Kanyi, H.; Maina, S.; Wang, D.E.; Ngugi, P.; O’Connor, R.; Kamau, T.; Waithera, T.; Kimani, G.; Wamae, C.N.; et al. Infectious diarrhoea in antiretroviral therapy-naïve HIV/AIDS patients in Kenya. Trans. R. Soc. Trop. Med. Hyg. 2013, 107, 631–638. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- GBD Tuberculosis Collaborators. Global, regional, and national burden of tuberculosis, 1990–2016: Results from the Global Burden of Diseases, Injuries, and Risk Factors 2016 Study. Lancet Infect. Dis. 2018, 18, 1329–1349. [Google Scholar] [CrossRef] [Green Version]
- Dheda, K.; Gumbo, T.; Maartens, G.; Dooley, K.E.; McNerney, R.; Murray, M.; Furin, J.; Nardell, E.A.; London, L.; Lessem, E.; et al. The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis. Lancet Respir. Med. 2017. [Google Scholar] [CrossRef]
- Ndihokubwayo, J.B.; Yahaya, A.A.; Dester, A.T.; Ki-Zerbo, G.; Odei, E.A.; Keita, B.; Pana, A.P.; Nkhoma, W. Antimicrobial resistance in the African Region: Issues, challenges and actions proposed. Afr. Health Monit. 2013, 16, 27–30. [Google Scholar]
- Jinks, T.; Lee, N.; Sharland, M.; Rex, J.; Gertler, N.; Diver, M.; Jones, I.; Jones, K.; Mathewson, S.; Chiara, F.; et al. A time for action: antimicrobial resistance needs global response. Bull World Health Organ. 2016, 94, 558–558A. [Google Scholar] [CrossRef]
- Cox, J.A.; Vlieghe, E.; Mendelson, M.; Wertheim, H.; Ndegwa, L.; Villegas, M.V.; Gould, I.; Levy, H.G. Antibiotic stewardship in low- and middle-income countries: The same but different? Clin. Microbiol. Infect. 2017, 23, 812–818. [Google Scholar] [CrossRef] [Green Version]
- Mendelson, M.; Matsoso, M. The South African antimicrobial resistance strategy framework. AMR Control 2015, 54–61. Available online: https://www.fidssa.co.za/Content/Documents/2015_01.pdf (accessed on 16 July 2019).
- Schellack, N.; Bronkhorst, E.; Coetzee, R.; Godman, B.; Gous, A.G.S.; Kolman, S.; Labuschagne, Q.; Malan, L.; Messina, A.P.; Naested, C.; et al. SASOCP position statement on the pharmacist’s role in antibiotic stewardship 2018. S. Afr. J. Infect. Dis. 2018, 33, 28–35. [Google Scholar] [CrossRef] [Green Version]
- Valiquette, L.; Laupland, K.B. Antimicrobial shortages: Another hurdle for clinicians. Can. J. Infect. Dis. Med. Microbiol. 2015, 26, 67–68. [Google Scholar] [CrossRef]
- Gundlapalli, A.V.; Beekmann, S.E.; Graham, D.R.; Polgreen, P.M.; Members of the Emerging Infections Network. Antimicrobial agent shortages: The new norm for infectious diseases physicians. Open Forum Infect. Dis. 2018, 5, ofy068. [Google Scholar] [CrossRef] [Green Version]
- Quadri, F.; Mazer-Amirshahi, M.; Fox, E.R.; Hawley, K.L.; Pines, J.M.; Zocchi, M.S.; May, L. Antibacterial drug shortages from 2001 to 2013: Implications for clinical practice. Clin. Infect. Dis. 2015, 60, 1737–1742. [Google Scholar] [CrossRef] [Green Version]
- Gross, A.E.; Gupta, V.; Tabak, Y.P.; Johannes, R.S.; Srinivasan, A.; Bleasdale, S.C. The effect of a Piperacillin/Tazobactam shortage on antimicrobial prescribing and clostridium difficile risk in 88 US Medical Centers. Clin. Infect. Dis. 2017, 65, 613–618. [Google Scholar] [CrossRef] [PubMed]
- Plüss-Suard, C.; Pannatier, A.; Ruffieux, C.; Kronenberg, A.; Mühlemann, K.; Zanetti, G. Changes in the use of broad-spectrum antibiotics after cefepime shortage: A time series analysis. Antimicrob. Agents Chemother. 2012, 56, 989–994. [Google Scholar] [CrossRef] [PubMed]
- Hodes, R.; Price, I.; Bungane, N.; Toska, E.; Cluver, L. How front-line healthcare workers respond to stock-outs of essential medicines in the Eastern Cape Province of South Africa. S. Afr. Med. J. 2017, 107, 738–740. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Gonzalez, L.L. Medicine Shortages: A Hard Diagnosis. 2015. Available online: https://health-e.org.za/2015/11/16/medicine-shortages-a-hard-diagnosis/ (accessed on 12 July 2019).
- Stop Stock Outs. 2015 Stock Outs National Survey—Third Annual Report—South Africa. Doctors Without Borders (MSF), the Rural Doctors Association of Southern Africa (RuDASA), the Rural Health Advocacy Project (RHAP), the Treatment Action Campaign (TAC), SECTION27 and the Southern African HIV Clinicians Society (SAHIVSoc). 2016. Available online: https://stockouts.org/Download/2015_stock_outs_national_survey.pdf (accessed on 12 July 2019).
- Meyer, J.C.; Schellack, N.; Stokes, J.; Lancaster, R.; Zeeman, H.; Defty, D.; Godman, B.; Steel, G. Ongoing initiatives to improve the quality and efficiency of medicine use within the public healthcare system in South Africa; A preliminary study. Front. Pharmacol. 2017, 8, 751. [Google Scholar] [CrossRef] [Green Version]
- McKenzie, A.; McCann, T. Evaluation of the Stop Stock Outs Project (SSP), South Africa. Technical Report. 2016. Available online: https://www.researchgate.net/publication/317003877_EVALUATION_OF_THE_STOP_STOCK_OUTS_PROJECT_SSP_SOUTH_AFRICA (accessed on 12 July 2019).
- Stop Stock Outs. 4th National Survey Report (2017)—The Fragile System. 2018. Available online: https://sahivsoc.org/FileUpload/Stop%20Stockouts%20National%20Report%20Oct%202018.pdf (accessed on 12 July 2019).
- Gundlapalli, A.V.; Beekmann, S.E.; Graham, D.R.; Polgreen, P.M. Perspectives and concerns regarding antimicrobial agent shortages among infectious disease specialists. Diagn. Microbiol. Infect. Dis. 2013, 75, 256–259. [Google Scholar] [CrossRef]
- Pulcini, C.; Beovic, B.; Beraud, G.; Carlet, J.; Cars, O.; Howard, P.; Levy-Hara, G.; Li, G.; Nathwani, D.; Roblot, F.; et al. Ensuring universal access to old antibiotics: A critical but neglected priority. Clin. Microbiol. Infect. 2017, 23, 590–592. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Tyler, L.S.; Cole, S.W.; May, J.R.; Millares, M.; Valentino, M.A.; Vermeulen, L.J.; Wilson, A.L.; ASHP Expert Panel on Formulary Management. ASHP guidelines on the pharmacy and therapeutics committee and the formulary system. Am. J. Health Syst. Pharm. 2008, 65, 1272–1283. [Google Scholar] [CrossRef]
- Mashaba, T.P.; Matlala, M.; Godman, B.; Meyer, J.C. Implementation and monitoring of decisions by pharmacy and therapeutics committees in South African public sector hospitals. Expert Rev. Clin. Pharmacol. 2019, 12, 159–168. [Google Scholar] [CrossRef]
- Matlala, M.; Gous, A.G.; Godman, B.; Meyer, J.C. Structure and activities of pharmacy and therapeutics committees among public hospitals in South Africa; findings and implications. Expert Rev. Clin. Pharmacol. 2017, 10, 1273–1280. [Google Scholar] [CrossRef] [Green Version]
- Department of Health, Republic of South Africa. Policy for Classifying Medicines into Therapeutic Classes for Purposes of Therapeutic Interchange; Department of Health, Republic of South Africa: Pretoria, South Africa, 2017.
- Gray, T.; Bertch, K.; Galt, K.; Gonyeau, M.; Karpiuk, E.; Oyen, L.; Sudekum, M.J.; Vermeulen, L.C. Guidelines for therapeutic interchange—2004. Pharmacotherapy 2005, 25, 1666–1680. [Google Scholar] [CrossRef] [Green Version]
- Kaakeh, R.; Sweet, B.V.; Reilly, C.; Bush, C.; DeLoach, S.; Higgins, B.; Clark, A.M.; Stevenson, J. Impact of drug shortages on U.S. health systems. Am. J. Health Syst. Pharm. 2011, 68, 1811–1819. [Google Scholar] [CrossRef] [PubMed]
- Griffith, M.M.; Pentoney, Z.; Scheetz, M.H. Antimicrobial drug shortages: A crisis amidst the epidemic and the need for antimicrobial stewardship efforts to lessen the effects. Pharmacotherapy 2012, 32, 665–667. [Google Scholar] [CrossRef] [PubMed]
- McLaughlin, M.; Kotis, D.; Thomson, K.; Harrison, M.; Fennessy, G.; Postelnick, M.; Scheetz, M.H. Effects on patient care caused by drug shortages: A survey. J. Manag. Care Pharm. 2013, 19, 783–788. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- WHO; WHO Collaborating Centre for Drug Statistics Methodology. Guidelines for ATC Classification and DDD Assignment; WHO; WHO Collaborating Centre for Drug Statistics Methodology: Oslo, Norway, 2017. [Google Scholar]
- Caulder, C.R.; Mehta, B.; Bookstaver, P.B.; Sims, L.D.; Stevenson, B. Impact of drug shortages on health system pharmacies in the Southeastern United States. Hosp. Pharm. 2015, 50, 279–286. [Google Scholar] [CrossRef] [Green Version]
- Harbarth, S.; Filius, P.M.; Natsch, S.; MacKenzie, F.M.; Gyssens, I.C. Shortage of antimicrobial agents in Europe: Results of an international survey. In Proceedings of the 17th European Congress of Clinical Microbiology and Infectious Diseases, Munich, Germany, 31 March–3 April 2007. [Google Scholar]
- Institute for Safe Medication Practices. Drug Shortages Continue to Compromise Patient Care. 2018. Available online: https://www.ismp.org/resources/drug-shortages-continue-compromise-patient-care (accessed on 12 July 2019).
- The Society of Hospital Pharmacists of Australia (SHPA). Medicine Shortages in Australia: A Snapshot of Shortages in Australian Hospitals; SHPA: Collingwood, Australia, 2017. [Google Scholar]
- Ventola, C.L. The drug shortage crisis in the United States: Causes, impact, and management strategies. P T. 2011, 36, 740–757. [Google Scholar]
- NDOH. National Drug Policy for South Africa. Available online: http://apps.who.int/medicinedocs/documents/s17744en/s17744en.pdf (accessed on 12 July 2019).
- Nakwatumbah, S.; Kibuule, D.; Godman, B.; Haakuria, V.; Kalemeera, F.; Baker, A.; Mubita, M. Compliance to guidelines for the prescribing of antibiotics in acute infections at Namibia’s national referral hospital: A pilot study and the implications. Expert Rev. Anti. Infect. Ther. 2017, 15, 713–721. [Google Scholar] [CrossRef] [Green Version]
- Van der Sandt, N.; Schellack, N.; Mabope, L.A.; Mawela, M.P.B.; Kruger, D.; Godman, B. Surgical antimicrobial prophylaxis among pediatric patients in South Africa comparing two healthcare settings. Pediatr. Infect. Dis. J. 2018, 38, 122–126. [Google Scholar] [CrossRef] [Green Version]
- Okoth, C.; Opanga, S.; Okalebo, F.; Oluka, M.; Baker, K.A.; Godman, B. Point prevalence survey of antibiotic use and resistance at a referral hospital in Kenya: Findings and implications. Hosp. Pract. 2018, 46, 128–136. [Google Scholar] [CrossRef] [Green Version]
- Alomi, Y.A.; Alghamdi, S.J.; Alattyh, R.A.; Shorog, E.; Alshahran, A.; Alasmary, S.; Alenazi, H.; Almutairi, A.; Almutairi, M. National survey of pharmacy practice at MOH hospitals in Saudi Arabia 2016–2017: Prescribing and medication management. J. Pharm. Pract. Community Med. 2018, 4, S54–S59. [Google Scholar] [CrossRef] [Green Version]
- World Health Organization. Addressing the Global Shortage of, and Access to, Medicines and Vaccines: Report by the Director-General. EB142/13. 2018. Available online: http://apps.who.int/gb/ebwha/pdf_files/EB142/B142_13-en.pdf (accessed on 12 July 2019).
Table 1.
Response rate and study population per province.
| Province | Target Population (n = 403) | Excluded from Target Population (n = 149) | Study Population (n = 254) | |||||
|---|---|---|---|---|---|---|---|---|
| No Approval Response | Approval Denied | Could not be Reached for an Email Address | Declined Participation/no Pharmacist/no Email or Fax | Email Delivered | Non-Response | Responses Per province (%) | ||
| Eastern Cape | 90 | 0 | 0 | 28 | 3 | 59 | 41 | 18 (21.2%) |
| Free State | 34 | 0 | 1 | 17 | 2 | 14 | 8 | 6 (7.1%) |
| Gauteng | 36 | 26 | 0 | 0 | 0 | 10 | 2 | 8 (9.4%) |
| Kwa-Zulu Natal | 77 | 0 | 0 | 7 | 0 | 70 | 57 | 13 (15.3%) |
| Limpopo | 40 | 0 | 0 | 4 | 0 | 36 | 28 | 8 (9.4%) |
| Mpumalanga | 33 | 0 | 0 | 11 | 1 | 21 | 17 | 4 (4.7%) |
| Northern Cape | 19 | 0 | 0 | 1 | 3 | 15 | 2 | 13 (15.3%) |
| North West | 20 | 0 | 0 | 1 | 1 | 18 | 10 | 8 (9.4%) |
| Western Cape | 54 | 20 | 10 | 12 | 1 | 11 | 4 | 7 (8.2%) |
| Total number (%) | 403 | 46 (11.4%) | 11 (2.7%) | 81 (20.1%) | 11 (2.7%) | 254 | 169 (66.5%) | 85 (33.5%) |
Table 2.
Demographic characteristics of respondents (n = 85).
| Respondents’ Characteristics | Respondents; n (%) | |
|---|---|---|
| Gender | Male | 31 (36.5%) |
| Female | 54 (63.5%) | |
| Age (years) | 20–30 | 19 (24.1%) |
| ˃30–40 | 28 (35.4%) | |
| ˃40–50 | 20 (25.3%) | |
| ˃50–65 | 12 (15.2%) | |
| Years of practice in the public sector | ≤10 | 51 (62.2%) |
| ˃10–20 | 24 (29.3%) | |
| ˃20–30 | 5 (6.1%) | |
| ˃30 | 2 (2.4%) | |
| Designation | Pharmacy manager | 41 (48.2%) |
| Pharmacist (completed community service; no specific designation) | 19 (22.4%) | |
| Procurement Pharmacist | 13 (15.3%) | |
| Drug controller | 10 (11.8%) | |
| Clinical Pharmacist | 4 (4.7%) | |
| Community Service Pharmacist | 4 (4.7%) | |
| Production Pharmacist | 2 (2.4%) | |
| Clinical supervisor | 1 (1.2%) | |
| Sub-district Pharmacist | 1 (1.2%) | |
| Level of care | District hospital | 43 (51.8%) |
| Regional hospital | 17 (20.5%) | |
| Tertiary hospital | 11 (13.3%) | |
| Specialised hospital | 10 (12.1%) | |
| Central hospital | 3 (3.6%) | |
Table 3.
Antimicrobial shortages by Anatomical Therapeutic Chemical classification.
| Antimicrobial Class | ATC Classification | Antimicrobial | Number of Respondents a | Total Number (%) Who Reported Antimicrobial as Unavailable | Average Duration of Shortages (days) |
|---|---|---|---|---|---|
| Penicillins | J01CF02 | Cloxacillin | 70 | 38 (54.3%) | 5 to >40 |
| J01CE08 | Benzathine Benzylpenicillin | 72 | 39 (54.2%) | 5 to >40 | |
| J01CE02 | Phenoxymethylpenicillin IV | 58 | 28 (48.3%) | 21 to >40 | |
| J01CE02 | Phenoxymethylpenicillin oral | 71 | 31 (43.7%) | 5 to >40 | |
| J01CE01 | Benzyl Penicillin | 72 | 24 (33.3%) | 5 to >40 | |
| J01CE09 | Procaine Penicillin | 55 | 14 (25.5%) | 21 to >40 | |
| J01CA01 | Ampicillin IV | 72 | 15 (20.8%) | 5 to >40 | |
| B-lactam inhibitor combinations | J01CR02 | Amoxicillin/Clavulanic Acid IV | 71 | 21 (29.6%) | 5 to >40 |
| J01CR05 | Piperacillin/Tazobactam | 61 | 16 (26.2%) | 5 to 40 | |
| Macrolides | J01FA01 | Erythromycin | 53 | 21 (39.6%) | 5 to >40 |
| J01FA10 | Azithromycin IV | 59 | 11 (18.6%) | 11 to 40 | |
| Cephalosporins | J01DD04 | Ceftriaxone | 71 | 27 (38.0%) | 5 to >40 |
| J01DE01 | Cefepime | 53 | 14 (26.4%) | 5 to >40 | |
| Aminoglycosides | J01GB03 | Gentamicin | 67 | 19 (28.4%) | 5 to >40 |
| Imidazole antifungal | D01AC01 | Clotrimazole cream | 71 | 20 (28.2%) | 5 to >40 |
| Glycopeptides | J01XA01 | Vancomycin Oral | 40 | 11 (27.5%) | >40 |
| J01XA01 | Vancomycin IV | 62 | 13 (21.0%) | 11 to 40 | |
| Synthetic nucleoside analogue antiviral | D06BB03 | Acyclovir IV | 58 | 14 (24.1%) | 5 to >40 |
| Tetraene polyene antifungal | D01AA02 | Natamycin | 43 | 8 (18.6%) | >40 |
| Polyene antifungal | J02AA01 | Amphotericin B | 72 | 13 (18.1%) | 5 to >40 |
a Total number of respondents who indicated the antimicrobial as either available or not available.
Table 4.
Reasons for, impact of, and procedures for reporting antimicrobial shortages.
| Reasons for Antimicrobial Shortages a | Hospital Level of Care | Total (%) (n = 75) | ||||
|---|---|---|---|---|---|---|
| District (n = 37) | Regional (n = 15) | Tertiary (n = 10) | Central (n = 3) | Specialised (n = 10) | ||
| Pharmaceutical companies with supply or capacity problems | 33 (51.6%) | 11 (17.2%) | 7 (10.9%) | 3 (4.7%) | 10 (15.6%) | 64 (85.3%) |
| Inefficient supply system from the depot to the facility | 31 (56.4%) | 10 (11.1%) | 8 (14.5%) | 1 (1.8%) | 5 (9.1%) | 55 (73.3%) |
| Poor stock control systems | 9 (50.0%) | 5 (27.8%) | 2 (11.1%) | 0 (0.0%) | 2 (11.1%) | 18 (24.0%) |
| Shortage of funds/resources | 9 (50.0%) | 5 (27.8%) | 2 (11.1%) | 1 (5.6%) | 1 (5.6%) | 18 (24.0%) |
| Wastage of medicines | 5 (35.7%) | 3 (21.4%) | 3 (21.4%) | 1 (7.1%) | 2 (14.3%) | 14 (18.7%) |
| Increase in the number of patients relying on facility for medication | 7 (50.0%) | 4 (28.6%) | 2 (14.3%) | 0 (0.0%) | 1 (7.1%) | 14 (18.7%) |
| Lack of reliable information on medicine needs and usage | 4 (33.3%) | 4 (33.3%) | 4 (33.3%) | 0 (0.0%) | 0 (0.0%) | 12 (16.0%) |
| Unclear lines of accountability | 5 (71.4%) | 0 (0.0%) | 1 (14.3%) | 0 (0.0%) | 1 (14.3%) | 7 (9.3%) |
| Poor ordering practices by pharmacists or nurses | 4 (80.0%) | 0 (0.0%) | 1 (20.0%) | 0 (0.0%) | 0 (0.0%) | 5 (6.7%) |
| Protest action resulting in shut down of depot | 4 (80.0%) | 1 (20.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 5 (6.7%) |
| Lack of storage facilities for medicines | 3 (100.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 3 (4.0%) |
| Unapproved tenders/changes to tender | 0 (0.0%) | 1 (50.0%) | 1 (50.0%) | 0 (0.0%) | 0 (0.0%) | 2 (2.7%) |
| Need to motivate for drugs | 0 (0.0%) | 1 (100.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 1 (1.3%) |
| Requested quantities too small for depot to supply | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 1 (100.0%) | 1 (1.3%) |
| Impact of antimicrobial shortages a | District (n = 37) | Regional (n = 16) | Tertiary (n = 11) | Central (n = 3) | Specialised (n = 10) | Total (%) (n = 77) |
| Dispensed second/third/fourth generation antimicrobials | 35 (53.8%) | 14 (21.5%) | 10 (15.4%) | 2 (3.1%) | 6 (9.2%) | 65 (84.4%) |
| Dispensed more expensive alternatives | 26 (52.0%) | 12 (24.0%) | 9 (18.0%) | 1 (2.0%) | 2 (4.0%) | 50 (64.9%) |
| Turned patient away with no medication | 14 (63.6%) | 3 (13.6%) | 2 (9.1%) | 1 (4.5%) | 2 (9.1%) | 22 (28.6%) |
| Referred patient to a private institution | 10 (55.6%) | 3 (16.7%) | 4 (22.2%) | 0 (0.0%) | 1 (5.6%) | 18 (23.4%) |
| Procedure for reporting shortages a | District (n = 35) | Regional (n = 17) | Tertiary (n = 8) | Central (n = 1) | Specialised (n = 7) | Total (%) (n = 68) |
| Weekly reports to central/provincial office or district pharmacist | 14 (53.8%) | 5 (19.2%) | 3 (11.5%) | 0 (0.0%) | 4 (15.4%) | 26 (38.2%) |
| Report to PTC | 6 (40.0%) | 4 (26.7%) | 3 (20.0%) | 0 (0.0%) | 2 (13.3%) | 15 (22.1%) |
| Update on inventory management system/out of stock book | 8 (61.5%) | 4 (30.8%) | 1 (7.7%) | 0 (0.0%) | 0 (0.0%) | 13 (19.1%) |
| Notify prescribers via telephone, email, meetings, SOPs or notices | 8 (61.5%) | 2 (15.4%) | 2 (15.4%) | 0 (0.0%) | 1 (7.7%) | 13 (19.1%) |
| Notify pharmacy management | 4 (33.3%) | 4 (33.3%) | 3 (25.0%) | 1 (8.3%) | 0 (0.0%) | 12 (17.6%) |
| Notify the depot | 5 (62.5%) | 2 (25.0%) | 1 (12.5%) | 0 (0.0%) | 0 (0.0%) | 8 (11.8%) |
| Report to CEO and PTC | 3 (42.9%) | 1 (14.3%) | 1 (14.3%) | 0 (0.0%) | 2 (28.6%) | 7 (10.3%) |
| Not available | 3 (100.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 3 (4.4%) |
a More than one response option provided. CEO: Chief Executive Officer; PTC: Pharmacy and Therapeutics Committee; SOP: Standard Operating Procedure.
Table 5.
Therapeutic interchange process by hospital level of care.
| Therapeutic interchange Process | Hospital Level of Care | |||||
|---|---|---|---|---|---|---|
| Therapeutic interchange policy description | District (n = 18) | Regional (n = 11) | Tertiary (n = 5) | Central (n = 1) | Specialised (n = 4) | Total (%) (n = 39) |
| Memo from National Department of Health | 6 (46.2%) | 5 (38.5%) | 1 (7.7%) | 1 (7.7%) | 0 (0.0%) | 13 (33.3%) |
| SOP/guidelines from PTCs | 7 (77.8%) | 2 (22.2%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 9 (23.1%) |
| Not available | 1 (14.3%) | 1 (14.3%) | 3 (42.9 | 0 (0.0%) | 2 (28.6%) | 7 (17.9%) |
| Hospital notice with alternatives/supplementary list | 2 (50.0%) | 2 (50.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 4 (10.3%) |
| Internal arrangement between pharmacists and prescribers | 1 (25.0%) | 1 (25.0%) | 0 (0.0%) | 0 (0.0%) | 2 (50.0%) | 4 (10.3%) |
| Alternatives from the depot | 1 (50.0%) | 0 (0.0%) | 1 (50.0%) | 0 (0.0%) | 0 (0.0%) | 2 (5.1%) |
| Health personnel responsible for development of therapeutic interchange policies a | District (n = 39) | Regional (n = 17) | Tertiary (n = 11) | Provincial (n = 3) | Specialised (n = 10) | Total (%) (n = 82) |
| Pharmacy and Therapeutics Committee | 25 (61.0%) | 6 (14.6%) | 3 (7.3%) | 3 (7.3%) | 4 (9.8%) | 41 (50.0%) |
| Pharmacist | 12 (46.2%) | 5 (19.2%) | 5 (19.2%) | 2 (7.7%) | 2 (7.7%) | 26 (31.7%) |
| Prescribers | 9 (45.0%) | 3 (15.0%) | 3 (15.0%) | 1 (5.0%) | 4 (20.0%) | 20 (24.4%) |
| National Department of Health | 1 (33.3%) | 2 (66.7%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 3 (3.7%) |
| Microbiologist | 0 (0.0%) | 2 (100.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 2 (2.4%) |
| Operational manager (registered nurses) | 1 (100.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 1 (1.2%) |
| Not applicable | 10 (45.5%) | 6 (27.3%) | 4 (18.2%) | 0 (0.0%) | 2 (9.1%) | 22 (26.8%) |
| Actions taken by the pharmacist during the therapeutic interchange process a | District (n = 41) | Regional (n = 17) | Tertiary (n = 11) | Provincial (n = 3) | Specialised (n = 10) | Total (%) (n = 82) |
| Communicate with other health professionals regarding any ongoing medicine shortages and available substitutions | 39 (50.6%) | 16 (20.8%) | 10 (13.0%) | 2 (2.6%) | 10 (13.0%) | 77 (93.9%) |
| Keep a record of the interchange | 25 (49.0%) | 10 (19.6%) | 8 (15.7%) | 2 (3.9%) | 6 (11.8%) | 51 (62.2%) |
| Patient counselling | 28 (68.3%) | 4 (9.8%) | 6 (14.6%) | 1 (2.4%) | 2 (4.8%) | 41 (50.0%) |
| None | 2 (100.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 2 (2.4%) |
| Provide prescribers with information on new therapeutic equivalent and correct dosages | 1 (100.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 1 (1.2%) |
| Antimicrobial substitution procedures, followed by pharmacists, in the absence of therapeutic interchange policies a | District (n = 42) | Regional (n = 17) | Tertiary (n = 11) | Central (n = 2) | Specialised (n = 9) | Total (%) (n = 81) |
| Call to notify the prescriber, avail the options and they choose/endorse change before dispensing alternative | 38 (52.8%) | 14 (19.4%) | 10 (13.9%) | 3 (4.2%) | 7 (9.7%) | 72 (88.9%) |
| Send a written memo to the prescribers supplying the available options | 19 (40.4%) | 14 (29.8%) | 7 (14.9%) | 3 (6.4%) | 4 (8.5%) | 47 (58.0%) |
| Send the patient back to the prescriber | 10 (45.5%) | 7 (31.8%) | 2 (9.1%) | 1 (4.5%) | 2 (9.1%) | 22 (27.2%) |
| Consult pharmacists at tertiary level for alternatives | 1 (100.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 1 (1.2%) |
| Borrow or buy out from other institutions | 1 (100.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 1 (1.2%) |
| Urgent meeting by Rational Medicines Use Committee to discuss way forward | 1 (100.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 1 (1.2%) |
a More than one response option provided.
Table 6.
Perceived role of the pharmacist in the therapeutic interchange process.
| Role of the Pharmacist | Hospital Level of Care | Total (%) (n = 70) | ||||
|---|---|---|---|---|---|---|
| District (n = 36) | Regional (n = 16) | Tertiary (n = 9) | Central (n = 1) | Specialised (n = 8) | ||
| Share information and communicate with prescribers on rational medicine use and available therapeutic options | 12 (46.2%) | 6 (23.1%) | 4 (15.4%) | 1 (3.8%) | 3 (11.5%) | 26 (37.1%) |
| Facilitate therapeutic interchange policy development and/or selection of therapeutic alternatives in the PTC | 11 (68.8%) | 2 (12.5%) | 2 (12.5%) | 0 (0.0%) | 1 (6.3%) | 16 (22.9%) |
| Work as part of a team with clinicians to provide the best therapeutic alternatives for the patient | 6 (40.0%) | 4 (26.7%) | 2 (13.3%) | 0 (0.0%) | 3 (20.0%) | 15 (21.4%) |
| Participate in research with other health care professionals to make informed medicine choices | 2 (33.3%) | 2 (33.3%) | 1 (16.7%) | 0 (0.0%) | 1 (16.7%) | 6 (8.6%) |
| Interchange without consulting the prescriber to reduce patient waiting times if all the patient information is available | 2 (50.0%) | 2 (50.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 4 (5.7%) |
| Educate and counsel patients on changes to their treatment | 3 (100.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 3 (4.3%) |
PTC: Pharmacy and Therapeutics Committee.
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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MDPI and ACS Style
Chigome, A.K.; Matlala, M.; Godman, B.; Meyer, J.C. Availability and Use of Therapeutic Interchange Policies in Managing Antimicrobial Shortages among South African Public Sector Hospitals; Findings and Implications. Antibiotics 2020, 9, 4. https://doi.org/10.3390/antibiotics9010004
AMA Style
Chigome AK, Matlala M, Godman B, Meyer JC. Availability and Use of Therapeutic Interchange Policies in Managing Antimicrobial Shortages among South African Public Sector Hospitals; Findings and Implications. Antibiotics. 2020; 9(1):4. https://doi.org/10.3390/antibiotics9010004
Chicago/Turabian StyleChigome, Audrey K., Moliehi Matlala, Brian Godman, and Johanna C. Meyer. 2020. "Availability and Use of Therapeutic Interchange Policies in Managing Antimicrobial Shortages among South African Public Sector Hospitals; Findings and Implications" Antibiotics 9, no. 1: 4. https://doi.org/10.3390/antibiotics9010004
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