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Antibiotics 2018, 7(4), 94; https://doi.org/10.3390/antibiotics7040094

Antibiotic Activity of Actinobacteria from the Digestive Tract of Millipede Nedyopus dawydoffiae (Diplopoda)

1
Gause Institute of New Antibiotics, 119021 Moscow, Russia
2
Faculty of Soil Science, Lomonosov Moscow State University, 119991 Moscow, Russia
3
A.N. Severtsova Institute of Ecology and Evolution, Russian Academy of Sciences, 119071 Moscow, Russia
4
Joint Russian-Vietnamese Tropical Center, Ho Chi Minh City, Vietnam
*
Author to whom correspondence should be addressed.
Received: 10 September 2018 / Revised: 17 October 2018 / Accepted: 24 October 2018 / Published: 29 October 2018
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Abstract

Because of the spread of drug resistance, it is necessary to look for new antibiotics that are effective against pathogenic microorganisms. The purpose of this study was to analyse the species composition of actinobacteria isolated from the digestive tract of the millipedes Nedyopus dawydoffiae and to determine their antimicrobial properties. Species identification was carried out on the basis of the morphological and culture properties and the sequence of the 16S rRNA gene. Actinobacteria were grown in different liquid media. Antibiotic properties were determined against some Gram-positive and Gram-negative bacteria as well as fungi. Of the 15 isolated strains, 13 have antibiotic activity against Gram-positive bacteria (including methicillin-resistant Staphylococcus aureus—MRSA) and fungi, but there was no antibiotic activity against Gram-negative test strains Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853. It was established that antibiotic-producing actinobacteria belong to eight species of the genus Streptomyces. Depending on the nutrient medium, actinobacteria demonstrate different antimicrobial activities. As an example, S. hydrogenans shows that even strains selected in one population differ by the range of antimicrobial activity and the level of biosynthesis. Since the antibiotic production is considered as a feature for species competition in the microbiota community, the variability of antibiotic production among different strains of the same species is an adaptive characteristic for the competition in millipedes’ digestive tract community. View Full-Text
Keywords: Streptomyces spp.; Nedyopus dawydoffiae; Diplopoda; microbiota; antibiotic activity; drug resistance Streptomyces spp.; Nedyopus dawydoffiae; Diplopoda; microbiota; antibiotic activity; drug resistance
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Glukhova, A.A.; Karabanova, A.A.; Yakushev, A.V.; Semenyuk, I.I.; Boykova, Y.V.; Malkina, N.D.; Efimenko, T.A.; Ivankova, T.D.; Terekhova, L.P.; Efremenkova, O.V. Antibiotic Activity of Actinobacteria from the Digestive Tract of Millipede Nedyopus dawydoffiae (Diplopoda). Antibiotics 2018, 7, 94.

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