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Bacteriophages: Protagonists of a Post-Antibiotic Era
Open AccessCase Report

Resolving Digital Staphylococcal Osteomyelitis Using Bacteriophage—A Case Report

PhageBiotics Research Foundation and Grays Harbor Community Hospital, Aberdeen, WA 98520, USA
PhageBiotics Research Foundation, The Evergreen State College, 2700 Evergreen Parkway NW, Olympia, WA 98505, USA
PhageBiotics Research Foundation, Saint Peter Hospital Family Medicine Residency, Olympia, WA 98505, USA
VA Northern California, Muir Road, Martinez, CA 94553, USA
Author to whom correspondence should be addressed.
Antibiotics 2018, 7(4), 87;
Received: 28 August 2018 / Revised: 18 September 2018 / Accepted: 19 September 2018 / Published: 2 October 2018
(This article belongs to the Special Issue Bacteriophages: Alternatives to Antibiotics and Beyond)
Infections involving diabetic foot ulcers (DFU) are a major public health problem and have a substantial negative impact on patient outcomes. Osteomyelitis in an ulcerated foot substantially increases the difficulty of successful treatment. While literature suggests that osteomyelitis in selected patients can sometimes be treated conservatively, with no, or minimal removal of bone, we do not yet have clear treatment guidelines and the standard treatment failure fallback remains amputation. The authors report on the successful treatment, with a long term follow up, of a 63 YO diabetic female with distal phalangeal osteomyelitis using bacteriophage, a form of treatment offering the potential for improved outcomes in this era of escalating antibiotic resistance and the increasingly recognized harms associated with antibiotic therapy. View Full-Text
Keywords: Bacteriophages; diabetic foot ulcer; osteomyelitis; phage therapy; Staphylococcus aureus Bacteriophages; diabetic foot ulcer; osteomyelitis; phage therapy; Staphylococcus aureus
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Fish, R.; Kutter, E.; Bryan, D.; Wheat, G.; Kuhl, S. Resolving Digital Staphylococcal Osteomyelitis Using Bacteriophage—A Case Report. Antibiotics 2018, 7, 87.

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