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Going beyond the Control of Quorum-Sensing to Combat Biofilm Infections
Open AccessReview

Sub-Optimal Treatment of Bacterial Biofilms

by 1,2,3,†, 1,2,† and 1,2,*
1
Department of Molecular Biology, Umeå University, Umeå S-90187, Sweden
2
The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå S-90187, Sweden
3
Department of Clinical Microbiology, Umeå University, Umeå S-90185, Sweden
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Gordon Ramage
Antibiotics 2016, 5(2), 23; https://doi.org/10.3390/antibiotics5020023
Received: 12 November 2015 / Revised: 8 May 2016 / Accepted: 13 June 2016 / Published: 22 June 2016
(This article belongs to the Special Issue Biofilm Infection)
Bacterial biofilm is an emerging clinical problem recognized in the treatment of infectious diseases within the last two decades. The appearance of microbial biofilm in clinical settings is steadily increasing due to several reasons including the increased use of quality of life-improving artificial devices. In contrast to infections caused by planktonic bacteria that respond relatively well to standard antibiotic therapy, biofilm-forming bacteria tend to cause chronic infections whereby infections persist despite seemingly adequate antibiotic therapy. This review briefly describes the responses of biofilm matrix components and biofilm-associated bacteria towards sub-lethal concentrations of antimicrobial agents, which may include the generation of genetic and phenotypic variabilities. Clinical implications of bacterial biofilms in relation to antibiotic treatments are also discussed. View Full-Text
Keywords: biofilm development; sub-optimal treatment; antibiotic tolerance; anti-biofilm agents biofilm development; sub-optimal treatment; antibiotic tolerance; anti-biofilm agents
MDPI and ACS Style

Song, T.; Duperthuy, M.; Wai, S.N. Sub-Optimal Treatment of Bacterial Biofilms. Antibiotics 2016, 5, 23.

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