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Going beyond the Control of Quorum-Sensing to Combat Biofilm Infections
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Antibiotics 2016, 5(2), 23;

Sub-Optimal Treatment of Bacterial Biofilms

Department of Molecular Biology, Umeå University, Umeå S-90187, Sweden
The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå S-90187, Sweden
Department of Clinical Microbiology, Umeå University, Umeå S-90185, Sweden
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Gordon Ramage
Received: 12 November 2015 / Revised: 8 May 2016 / Accepted: 13 June 2016 / Published: 22 June 2016
(This article belongs to the Special Issue Biofilm Infection)
Full-Text   |   PDF [255 KB, uploaded 22 June 2016]


Bacterial biofilm is an emerging clinical problem recognized in the treatment of infectious diseases within the last two decades. The appearance of microbial biofilm in clinical settings is steadily increasing due to several reasons including the increased use of quality of life-improving artificial devices. In contrast to infections caused by planktonic bacteria that respond relatively well to standard antibiotic therapy, biofilm-forming bacteria tend to cause chronic infections whereby infections persist despite seemingly adequate antibiotic therapy. This review briefly describes the responses of biofilm matrix components and biofilm-associated bacteria towards sub-lethal concentrations of antimicrobial agents, which may include the generation of genetic and phenotypic variabilities. Clinical implications of bacterial biofilms in relation to antibiotic treatments are also discussed. View Full-Text
Keywords: biofilm development; sub-optimal treatment; antibiotic tolerance; anti-biofilm agents biofilm development; sub-optimal treatment; antibiotic tolerance; anti-biofilm agents
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Song, T.; Duperthuy, M.; Wai, S.N. Sub-Optimal Treatment of Bacterial Biofilms. Antibiotics 2016, 5, 23.

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