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Antibiotics 2016, 5(2), 15;

Antibiotics and RNase P

Department of Biological Chemistry, School of Medicine, University of Patras, Rio-Patras 26504, Greece
Academic Editor: Claudio O. Gualerzi
Received: 12 March 2016 / Revised: 22 April 2016 / Accepted: 3 May 2016 / Published: 6 May 2016
(This article belongs to the Special Issue Inhibitors of the Translational Apparatus)
Full-Text   |   PDF [524 KB, uploaded 6 May 2016]   |  


RNase P is an essential endonuclease in tRNA biogenesis, which generates the mature 5′-termini of tRNAs. Most forms of RNase P are ribonucleoproteins, i.e., they consist of an essential RNA and protein subunits. The catalytic function of ribonucleoprotein RNase P enzymes resides entirely in the RNA subunit. Its high structural and functional diversity among representatives of a vast variety of phylogenetic domains indicates that RNase P could serve as a molecular target and a useful screening system for the development of new drugs in the battle against bacterial drug resistance. View Full-Text
Keywords: RNase P; neomycin B; neomycin sulfate; puromycin; morpholino oligonucleotides RNase P; neomycin B; neomycin sulfate; puromycin; morpholino oligonucleotides

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Drainas, D. Antibiotics and RNase P. Antibiotics 2016, 5, 15.

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