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Antibiotics 2015, 4(1), 1-17;

The Role of Antifungals against Candida Biofilm in Catheter-Related Candidemia

Department of Clinical Microbiology and Infectious Diseases, Gregorio Marañón Hospital, Madrid 28007, Spain
Medicine Department, School of Medicine, Universidad Complutense de Madrid, Madrid 28040, Spain
CIBER de Enfermedades Respiratorias (CIBER RES), CB06/06/0058, Madrid, Spain
Author to whom correspondence should be addressed.
Academic Editor: Christopher C. Butler
Received: 11 October 2014 / Accepted: 9 December 2014 / Published: 25 December 2014
Full-Text   |   PDF [634 KB, uploaded 25 December 2014]


Catheter-related bloodstream infection (C-RBSI) is one of the most frequent nosocomial infections. It is associated with high rates of morbidity and mortality. Candida spp. is the third most common cause of C-RBSI after coagulase-negative staphylococci and Staphylococcus aureus and is responsible for approximately 8% of episodes. The main cause of catheter-related candidemia is the ability of some Candida strains—mainly C. albicans and C. parapsilosis—to produce biofilms. Many in vitro and in vivo models have been designed to assess the activity of antifungal drugs against Candida biofilms. Echinocandins have proven to be the most active antifungal drugs. Potential options in situations where the catheter cannot be removed include the combination of systemic and lock antifungal therapy. However, well-designed and -executed clinical trials must be performed before firm recommendations can be issued. View Full-Text
Keywords: biofilm; Candida; antifungals; catheter-related candidemia biofilm; Candida; antifungals; catheter-related candidemia
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Bouza, E.; Guinea, J.; Guembe, M. The Role of Antifungals against Candida Biofilm in Catheter-Related Candidemia. Antibiotics 2015, 4, 1-17.

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