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An Environmental Risk Assessment for Human-Use Trimethoprim in European Surface Waters

F. Hoffmann-La Roche Ltd., Group SHE, CH-4070 Basle, Switzerland
Antibiotics 2013, 2(1), 115-162; https://doi.org/10.3390/antibiotics2010115
Received: 23 November 2012 / Revised: 10 January 2013 / Accepted: 14 January 2013 / Published: 18 March 2013
(This article belongs to the Special Issue The Environmental Footprint of Antibiotics)
An environmental risk assessment (ERA) for the aquatic compartment in Europe from human use was developed for the old antibiotic Trimethoprim (TMP), comparing exposure and effects. The exposure assessment is based on European risk assessment default values on one hand and is refined with documented human use figures in Western Europe from IMS Health and measured removal in wastewater treatment on the other. The resulting predicted environmental concentrations (PECs) are compared with measured environmental concentrations (MECs) from Europe, based on a large dataset incorporating more than 1800 single MECs. On the effects side, available chronic ecotoxicity data from the literature were complemented by additional, new chronic results for fish and other organisms. Based on these data, chronic-based deterministic predicted no effect concentrations (PNECs) were derived as well as two different probabilistic PNEC ranges. The ERA compares surface water PECs and MECs with aquatic PNECs for TMP. Based on all the risk characterization ratios (PEC÷PNEC as well as MEC÷PNEC) and risk graphs, there is no significant risk to surface waters. View Full-Text
Keywords: trimethoprim; environmental exposure; environmental effects; environmental risk assessment; surface waters; Europe trimethoprim; environmental exposure; environmental effects; environmental risk assessment; surface waters; Europe
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Straub, J.O. An Environmental Risk Assessment for Human-Use Trimethoprim in European Surface Waters. Antibiotics 2013, 2, 115-162.

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