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Brief Report

A Universal LC-MS/MS Method for Simultaneous Detection of Antibiotic Residues in Animal and Environmental Samples

1
School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
2
HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
3
The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, China
4
Microbiota I-Center (MagIC), The Chinese University of Hong Kong, Hong Kong SAR, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Alain Bousquet-Mélou
Antibiotics 2022, 11(7), 845; https://doi.org/10.3390/antibiotics11070845
Received: 24 May 2022 / Revised: 12 June 2022 / Accepted: 20 June 2022 / Published: 24 June 2022
Detecting and monitoring the usage of antibiotics is a critical aspect of efforts to combat antimicrobial resistance. Antibiotic residue testing with existing LC-MS/MS methods is limited in detection range. Current methods also lack the capacity to detect multiple antibiotic residues in different samples simultaneously. In this study, we demonstrate a methodology that permits simultaneous extraction and detection of antibiotic residues in animal and environmental samples. A total of 30 different antibiotics from 13 classes could be qualitatively detected with our methodology. Further study to reduce analytes’ matrix effect would allow for quantification of antibiotic residues. View Full-Text
Keywords: antibiotic residue; solid-phase extraction; LC-MS/MS antibiotic residue; solid-phase extraction; LC-MS/MS
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MDPI and ACS Style

Chan, C.-L.; Wai, H.K.-F.; Wu, P.; Lai, S.-W.; Chan, O.S.-K.; Tun, H.M. A Universal LC-MS/MS Method for Simultaneous Detection of Antibiotic Residues in Animal and Environmental Samples. Antibiotics 2022, 11, 845. https://doi.org/10.3390/antibiotics11070845

AMA Style

Chan C-L, Wai HK-F, Wu P, Lai S-W, Chan OS-K, Tun HM. A Universal LC-MS/MS Method for Simultaneous Detection of Antibiotic Residues in Animal and Environmental Samples. Antibiotics. 2022; 11(7):845. https://doi.org/10.3390/antibiotics11070845

Chicago/Turabian Style

Chan, Chak-Lun, Hogan Kok-Fung Wai, Peng Wu, Siu-Wai Lai, Olivia Sinn-Kay Chan, and Hein M. Tun. 2022. "A Universal LC-MS/MS Method for Simultaneous Detection of Antibiotic Residues in Animal and Environmental Samples" Antibiotics 11, no. 7: 845. https://doi.org/10.3390/antibiotics11070845

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