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Brief Report

Efficacy of Three Povidone Iodine Formulations against Cutibacterium acnes Assessed through In Vitro Studies: A Preliminary Study

1
Bacteriology Laboratory Poitiers, Infectious Agents Department, Pharmacology of Antimicrobial Agents and Antibioresistance, Faculté de Médecine et Pharmacie, University Hospital of Poitiers, INSERM U1070, 86034 Poitiers, France
2
Mylan, A Viatris Company, 75008 Paris, France
3
Meda Pharma S.P.A., A Viatris Company, 20900 Monza, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Philip W. Wertz
Antibiotics 2022, 11(5), 665; https://doi.org/10.3390/antibiotics11050665
Received: 29 March 2022 / Revised: 11 May 2022 / Accepted: 14 May 2022 / Published: 16 May 2022
(This article belongs to the Section Mechanisms of Antibiotic Action)
Cutibacterium acnes (C. acnes, formerly known as Propionibacterium acnes) is the major causative agent of prosthetic joint infections (PJI). Treatment of PJI with antibiotics is difficult due to antibiotic resistance and adverse side effects on patients’ health. Proper disinfection of the surgical site using a variety of povidone iodine formulations could prevent C. acnes infection. In the current study, the efficacy of the three povidone iodine (PVP-I) formulations, viz: PVP-I 10% dermic solution, PVP-I 5% alcoholic solution and PVP-I 4% scrub, was tested against C. acnes, in vitro, in the presence of interfering substances mimicking soiling conditions. C. acnes strain ATCC 6919 was used to test the bactericidal activity of the povidone iodine formulations according to the modified dilution-neutralization method described in French Norm EN standard 13727. A 3-log reduction in the bacterial cell count in 60 s was considered to be significant. The results showed that under experimental conditions, the three PVP-I formulations displayed bactericidal activity against the micro-organism, Cutibacterium acnes, and that the lowest concentration of povidone-iodine active against C. acnes was 0.4%. These results are encouraging as PVP-I offers a low-cost and efficient method of disinfection. View Full-Text
Keywords: Cutibacterium acnes; skin microbiota; antiseptic; microbiology; prosthetic joint infection Cutibacterium acnes; skin microbiota; antiseptic; microbiology; prosthetic joint infection
MDPI and ACS Style

Pichon, M.; Burucoa, C.; Evplanov, V.; Favalli, F. Efficacy of Three Povidone Iodine Formulations against Cutibacterium acnes Assessed through In Vitro Studies: A Preliminary Study. Antibiotics 2022, 11, 665. https://doi.org/10.3390/antibiotics11050665

AMA Style

Pichon M, Burucoa C, Evplanov V, Favalli F. Efficacy of Three Povidone Iodine Formulations against Cutibacterium acnes Assessed through In Vitro Studies: A Preliminary Study. Antibiotics. 2022; 11(5):665. https://doi.org/10.3390/antibiotics11050665

Chicago/Turabian Style

Pichon, Maxime, Christophe Burucoa, Victor Evplanov, and Filippo Favalli. 2022. "Efficacy of Three Povidone Iodine Formulations against Cutibacterium acnes Assessed through In Vitro Studies: A Preliminary Study" Antibiotics 11, no. 5: 665. https://doi.org/10.3390/antibiotics11050665

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