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Review

Carbon Quantum Dots Derived from Different Carbon Sources for Antibacterial Applications

1
University of Groningen and University Medical Center of Groningen, Department of Orthodontics, Hanzeplein 1, 9700 RB Groningen, The Netherlands
2
College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren’ai Rd, Suzhou 215123, China
3
University of Groningen and University Medical Center Groningen, Department of Biomedical Engineering, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
*
Author to whom correspondence should be addressed.
Academic Editors: Alan J. Hibbitts and Sofia A. Papadimitriou
Antibiotics 2021, 10(6), 623; https://doi.org/10.3390/antibiotics10060623
Received: 20 April 2021 / Revised: 19 May 2021 / Accepted: 19 May 2021 / Published: 24 May 2021
(This article belongs to the Special Issue Nanoparticles-Based Antimicrobials)
Nanoparticles possess unique features due to their small size and can be composed of different surface chemistries. Carbon quantum dots possess several unique physico-chemical and antibacterial activities. This review provides an overview of different methods to prepare carbon quantum dots from different carbon sources in order to provide guidelines for choosing methods and carbon sources that yield carbon quantum dots with optimal antibacterial efficacy. Antibacterial activities of carbon quantum dots predominantly involve cell wall damage and disruption of the matrix of infectious biofilms through reactive oxygen species (ROS) generation to cause dispersal of infecting pathogens that enhance their susceptibility to antibiotics. Quaternized carbon quantum dots from organic carbon sources have been found to be equally efficacious for controlling wound infection and pneumonia in rodents as antibiotics. Carbon quantum dots derived through heating of natural carbon sources can inherit properties that resemble those of the carbon sources they are derived from. This makes antibiotics, medicinal herbs and plants or probiotic bacteria ideal sources for the synthesis of antibacterial carbon quantum dots. Importantly, carbon quantum dots have been suggested to yield a lower chance of inducing bacterial resistance than antibiotics, making carbon quantum dots attractive for large scale clinical use. View Full-Text
Keywords: nanoparticles; precursor; reactive oxygen species; photodynamic activity; biofilm; infection; size control; dispersal; antibiotics; synergy nanoparticles; precursor; reactive oxygen species; photodynamic activity; biofilm; infection; size control; dispersal; antibiotics; synergy
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MDPI and ACS Style

Wu, Y.; Li, C.; van der Mei, H.C.; Busscher, H.J.; Ren, Y. Carbon Quantum Dots Derived from Different Carbon Sources for Antibacterial Applications. Antibiotics 2021, 10, 623. https://doi.org/10.3390/antibiotics10060623

AMA Style

Wu Y, Li C, van der Mei HC, Busscher HJ, Ren Y. Carbon Quantum Dots Derived from Different Carbon Sources for Antibacterial Applications. Antibiotics. 2021; 10(6):623. https://doi.org/10.3390/antibiotics10060623

Chicago/Turabian Style

Wu, Yanyan, Cong Li, Henny C. van der Mei, Henk J. Busscher, and Yijin Ren. 2021. "Carbon Quantum Dots Derived from Different Carbon Sources for Antibacterial Applications" Antibiotics 10, no. 6: 623. https://doi.org/10.3390/antibiotics10060623

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