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Open AccessArticle

Pharmacological Potential and Chemical Characterization of Bridelia ferruginea Benth.—A Native Tropical African Medicinal Plant

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Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City 758307, Vietnam
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Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City 758307, Vietnam
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Department of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, Réduit 80837, Mauritius
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Physiology and Biochemistry Research Laboratory, Department of Biology, Science Faculty, Selcuk University, Konya 42130, Turkey
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Agricultural and Molecular Research and Service Institute, University of Nyíregyháza, 4400 Nyíregyháza, Hungary
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Department of Chemistry, Biology and Biotechnology, University of Perugia, 06100 Perugia, Italy
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Department of Pharmacy, Università degli Studi “Gabriele d’Annunzio”, via dei Vestini 31, 66100 Chieti, Italy
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Laboratoire de Botanique, UFR Biosciences, Université Félix Houphouët-Boigny, Abidjan 00225, Côte d’Ivoire
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Department of Life Sciences and Biotechnology (SVeB), UR7 Terra&Acqua Tech, University of Ferrara, 44121 Ferrara, Italy
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Authors to whom correspondence should be addressed.
Academic Editor: Eliana De Gregorio
Antibiotics 2021, 10(2), 223; https://doi.org/10.3390/antibiotics10020223
Received: 15 February 2021 / Revised: 19 February 2021 / Accepted: 20 February 2021 / Published: 23 February 2021
To avail the possible pharmacological actions of Brideliaferruginea Benth., the present investigation was designed to quantitatively analyze the total flavonoid and phenolic contents and assess the various antioxidant and enzyme inhibition properties of leaf and stem bark extracts (ethyl acetate, water and methanolic) of B. ferruginea. Anti-proliferative effect was also investigated against human colon cancer cells (HCT116) as well as the antimicrobial potential against multiple bacterial and fungal (yeasts and dermatophytes) strains. The methanolic and water extracts of the stem bark demonstrated the highest phenolic content (193.58 ± 0.98 and 187.84 ± 1.88 mg/g, respectively), while the leaf extracts showed comparatively higher flavonoid contents (24.37–42.31 mg/g). Overall, the methanolic extracts were found to possess the most significant antioxidant potency. Compared to the other extracts, methanolic extracts of the B. ferruginea were revealed to be most potent inhibitors of acetyl- and butyryl-cholinesterases, tyrosinase α-amylase, except α-glucosidase. Only the ethyl acetate extracts were found to inhibit glucosidase. Additionally, the stem bark methanolic extract also showed potent inhibitory activity against E. coli and gram-positive bacteria (MIC (minimum inhibitory concentration): 2.48–62.99 µg/mL), as well as all the tested fungi (MIC: 4.96–62.99 µg/mL). In conclusion, B. ferruginea can be regarded as a promising source of bioactive compounds displaying multifunctional pharmacological activities and thus is a potential candidate for further investigations in the endeavor to develop botanical formulations for pharmaceutical and cosmeceutical industries. View Full-Text
Keywords: Bridelia ferruginea; antidiabetic; anticholinesterase; antityrosinase; antioxidant; antimicrobial; antiproliferative Bridelia ferruginea; antidiabetic; anticholinesterase; antityrosinase; antioxidant; antimicrobial; antiproliferative
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MDPI and ACS Style

Mahomoodally, M.F.; Jugreet, S.; Sinan, K.I.; Zengin, G.; Ak, G.; Ceylan, R.; Jekő, J.; Cziáky, Z.; Angelini, P.; Angeles Flores, G.; Venanzoni, R.; Di Simone, S.C.; Menghini, L.; Orlando, G.; Ferrante, C.; Etienne, O.K.; Tacchini, M. Pharmacological Potential and Chemical Characterization of Bridelia ferruginea Benth.—A Native Tropical African Medicinal Plant. Antibiotics 2021, 10, 223. https://doi.org/10.3390/antibiotics10020223

AMA Style

Mahomoodally MF, Jugreet S, Sinan KI, Zengin G, Ak G, Ceylan R, Jekő J, Cziáky Z, Angelini P, Angeles Flores G, Venanzoni R, Di Simone SC, Menghini L, Orlando G, Ferrante C, Etienne OK, Tacchini M. Pharmacological Potential and Chemical Characterization of Bridelia ferruginea Benth.—A Native Tropical African Medicinal Plant. Antibiotics. 2021; 10(2):223. https://doi.org/10.3390/antibiotics10020223

Chicago/Turabian Style

Mahomoodally, Mohamad F.; Jugreet, Sharmeen; Sinan, Kouadio I.; Zengin, Gokhan; Ak, Gunes; Ceylan, Ramazan; Jekő, József; Cziáky, Zoltán; Angelini, Paola; Angeles Flores, Giancarlo; Venanzoni, Roberto; Di Simone, Simonetta C.; Menghini, Luigi; Orlando, Giustino; Ferrante, Claudio; Etienne, Ouattara K.; Tacchini, Massimo. 2021. "Pharmacological Potential and Chemical Characterization of Bridelia ferruginea Benth.—A Native Tropical African Medicinal Plant" Antibiotics 10, no. 2: 223. https://doi.org/10.3390/antibiotics10020223

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