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Article

Sanguiin H-6 Fractionated from Cloudberry (Rubus chamaemorus) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection

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Clinical Microbiology Department, IIS-Fundación Jiménez Díaz, UAM. Avda. Reyes Católicos 2, 28040 Madrid, Spain
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Networking Research Centre on Infectious Diseases (CIBER-ID), 28029 Madrid, Spain
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Infectious Diseases and Tropical Medicine Service, IIS-Fundación Jiménez Díaz, UAM. Avda. Reyes Católicos 2, 28040 Madrid, Spain
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Neumology Department, IIS-Fundación Jiménez Díaz, Universidad Autónoma de Madrid, CIBERES, 28040 Madrid, Spain
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VTT Technical Research Centre of Finland Ltd. Tietotie 2, FI-02150 Espoo, Finland
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Natural Chemistry Research Group, Department of Chemistry, University of Turku, FI-20014 Turku, Finland
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Clinical Microbiology Department, Hospital Universitario Príncipe de Asturias, 28805 Madrid, Spain
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Department of Biomedicine and Biotechnology, University of Alcalá, 28805 Alcalá de Henares, Spain
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Department of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital, University of Helsinki, P.O. Box 263, 00029 HUS, FI-00130 Helsinki, Finland
*
Authors to whom correspondence should be addressed.
These authors should be considered joint senior authors.
Academic Editors: Marcello Iriti, Elena Maria Varoni and Sara Vitalini
Antibiotics 2021, 10(12), 1481; https://doi.org/10.3390/antibiotics10121481
Received: 4 November 2021 / Revised: 25 November 2021 / Accepted: 29 November 2021 / Published: 3 December 2021
(This article belongs to the Special Issue Antimicrobial Plant Extracts and Phytochemicals, 2nd Volume)
Staphylococcus aureus is the most common cause of surgical site infections and its treatment is challenging due to the emergence of multi-drug resistant strains such as methicillin-resistant S. aureus (MRSA). Natural berry-derived compounds have shown antimicrobial potential, e.g., ellagitannins such as sanguiin H-6 and lambertianin C, the main phenolic compounds in Rubus seeds, have shown antimicrobial activity. The aim of this study was to evaluate the effect of sanguiin H-6 and lambertianin C fractionated from cloudberry seeds, on the MRSA growth, and as treatment of a MRSA biofilm development in different growth media in vitro and in vivo by using a murine wound infection model where sanguiin H-6 and lambertianin C were used to prevent the MRSA infection. Sanguiin H-6 and lambertianin C inhibited the in vitro biofilm development and growth of MRSA. Furthermore, sanguiin H-6 showed significant anti-MRSA effect in the in vivo wound model. Our study shows the possible use of sanguiin H-6 as a preventive measure in surgical sites to avoid postoperative infections, whilst lambertianin C showed no anti-MRSA activity. View Full-Text
Keywords: methicillin-resistant S. aureus; biofilm; cloudberry; Rubus; ellagitannin methicillin-resistant S. aureus; biofilm; cloudberry; Rubus; ellagitannin
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MDPI and ACS Style

Aguilera-Correa, J.J.; Fernández-López, S.; Cuñas-Figueroa, I.D.; Pérez-Rial, S.; Alakomi, H.-L.; Nohynek, L.; Oksman-Caldentey, K.-M.; Salminen, J.-P.; Esteban, J.; Cuadros, J.; Puupponen-Pimiä, R.; Perez-Tanoira, R.; Kinnari, T.J. Sanguiin H-6 Fractionated from Cloudberry (Rubus chamaemorus) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection. Antibiotics 2021, 10, 1481. https://doi.org/10.3390/antibiotics10121481

AMA Style

Aguilera-Correa JJ, Fernández-López S, Cuñas-Figueroa ID, Pérez-Rial S, Alakomi H-L, Nohynek L, Oksman-Caldentey K-M, Salminen J-P, Esteban J, Cuadros J, Puupponen-Pimiä R, Perez-Tanoira R, Kinnari TJ. Sanguiin H-6 Fractionated from Cloudberry (Rubus chamaemorus) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection. Antibiotics. 2021; 10(12):1481. https://doi.org/10.3390/antibiotics10121481

Chicago/Turabian Style

Aguilera-Correa, John Jairo, Sara Fernández-López, Iskra Dennisse Cuñas-Figueroa, Sandra Pérez-Rial, Hanna-Leena Alakomi, Liisa Nohynek, Kirsi-Marja Oksman-Caldentey, Juha-Pekka Salminen, Jaime Esteban, Juan Cuadros, Riitta Puupponen-Pimiä, Ramon Perez-Tanoira, and Teemu J. Kinnari. 2021. "Sanguiin H-6 Fractionated from Cloudberry (Rubus chamaemorus) Seeds Can Prevent the Methicillin-Resistant Staphylococcus aureus Biofilm Development during Wound Infection" Antibiotics 10, no. 12: 1481. https://doi.org/10.3390/antibiotics10121481

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