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Penicillins’ Solubility in Supercritical Carbon Dioxide: Modeling by Cubic Equations of States Revisited

by 1,2
1
Department of Pharmaceutical Engineering, Faculty of Process Engineering, University Constantine 3-Salah Boubnider, Constantine 25000, Algeria
2
Laboratoire ReMeDD, University Constantine 3-Salah Boubnider, Constantine 25000, Algeria
Academic Editor: Juan Ayala
Antibiotics 2021, 10(12), 1448; https://doi.org/10.3390/antibiotics10121448
Received: 6 October 2021 / Revised: 7 November 2021 / Accepted: 15 November 2021 / Published: 25 November 2021
Development of processes using green solvents as supercritical fluids (SCFs) depends on the accuracy of modeling and predicting phase equilibrium which is of considerable importance to exploit the use of SCF process at the level of pharmaceutical industries. Solid-Fluid equilibrium modeling is associated to many drawbacks when compressed gas-based models as cubic equations of states (cEoSs) are used. The unavailability of experimental values of solute’s sublimation pressure presents one of the major obstacles to the solubility modeling with this type of models, and thus, its estimation is essential and inevitable. This work is an attempt to address a question regarding “accurate estimated value” of sublimation pressure of two antibiotics Penicillin G (benzyl penicillin) and Penicillin V (phenoxymethyl penicillin). Toward that, first, cEoSs are provided as the thermodynamics modeling framework and fundamental approach. Second, a discussion and a review of some literature results are given. Third, results are invoked to present a criticism analysis that comes from the use of modified form of Peng-Robinson (PR) equation of states. Finally, considerable improvement of modeling results by using a new sublimation pressure is shown. View Full-Text
Keywords: supercritical CO2; Penicillin G; Penicillin V; solubility modeling; sublimation pressure; equations of state supercritical CO2; Penicillin G; Penicillin V; solubility modeling; sublimation pressure; equations of state
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MDPI and ACS Style

Nasri, L. Penicillins’ Solubility in Supercritical Carbon Dioxide: Modeling by Cubic Equations of States Revisited. Antibiotics 2021, 10, 1448. https://doi.org/10.3390/antibiotics10121448

AMA Style

Nasri L. Penicillins’ Solubility in Supercritical Carbon Dioxide: Modeling by Cubic Equations of States Revisited. Antibiotics. 2021; 10(12):1448. https://doi.org/10.3390/antibiotics10121448

Chicago/Turabian Style

Nasri, Loubna. 2021. "Penicillins’ Solubility in Supercritical Carbon Dioxide: Modeling by Cubic Equations of States Revisited" Antibiotics 10, no. 12: 1448. https://doi.org/10.3390/antibiotics10121448

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