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Article

Susceptibility to Nisin, Bactofencin, Pediocin and Reuterin of Multidrug Resistant Staphylococcus aureus, Streptococcus dysgalactiae and Streptococcus uberis Causing Bovine Mastitis

1
Sherbrooke Research and Development Centre, Agriculture and Agri-Food Canada, Sherbrooke, QC J1M 0C8, Canada
2
Département de Biologie, Faculté des Sciences, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada
3
Food Science Department, Food and Agriculture Faculty, Institute of Nutrition and Functional Foods, Laval University, 2425 Agriculture Street, Quebec City, QC G1V 0A6, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Seok Hoon Jeong
Antibiotics 2021, 10(11), 1418; https://doi.org/10.3390/antibiotics10111418
Received: 5 October 2021 / Revised: 4 November 2021 / Accepted: 12 November 2021 / Published: 19 November 2021
(This article belongs to the Special Issue Antimicrobial Resistance and Antibiotic Alternatives in Livestock)
Antibiotics are the most effective strategy to prevent and treat intramammary infections. However, their misuse has led to the dissemination of multidrug resistant bacteria (MDR) for both animals and humans. Efforts to develop new alternative strategies to control bacterial infections related to MDR are continuously on the rise. The objective of this study was to evaluate the antimicrobial activity of different bacteriocins and reuterin against MDR Staphylococcus and Streptococcus clinical isolates involved in bovine mastitis. A bacterial collection including S. aureus (n = 19), S. dysgalactiae (n = 17) and S. uberis (n = 19) was assembled for this study. Antibiotic resistance profiles were determined by the disk diffusion method. In addition, sensitivity to bacteriocins and reuterin was evaluated by determining minimum inhibitory concentrations (MIC). A total of 21 strains (37.5%) were MDR. MICs ranged from ≤1.0 μg/mL to ≥100 μg/mL for nisin and 2.0 to ≥250 μg/mL for bactofencin. Reuterin was active against all tested bacteria, and MICs vary between 70 and 560 μg/mL. Interestingly, 20 MDR strains were inhibited by bactofencin at a concentration of ≤250 μg/mL, while 14 were inhibited by nisin at an MIC of ≤100 μg/mL. Pediocin did not show an inhibitory effect. View Full-Text
Keywords: antibiotic resistance; bacteriocin; dairy cows; intramammary infection; alternative to antibiotics; reuterin antibiotic resistance; bacteriocin; dairy cows; intramammary infection; alternative to antibiotics; reuterin
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MDPI and ACS Style

Bennett, S.; Ben Said, L.; Lacasse, P.; Malouin, F.; Fliss, I. Susceptibility to Nisin, Bactofencin, Pediocin and Reuterin of Multidrug Resistant Staphylococcus aureus, Streptococcus dysgalactiae and Streptococcus uberis Causing Bovine Mastitis. Antibiotics 2021, 10, 1418. https://doi.org/10.3390/antibiotics10111418

AMA Style

Bennett S, Ben Said L, Lacasse P, Malouin F, Fliss I. Susceptibility to Nisin, Bactofencin, Pediocin and Reuterin of Multidrug Resistant Staphylococcus aureus, Streptococcus dysgalactiae and Streptococcus uberis Causing Bovine Mastitis. Antibiotics. 2021; 10(11):1418. https://doi.org/10.3390/antibiotics10111418

Chicago/Turabian Style

Bennett, Samantha, Laila Ben Said, Pierre Lacasse, François Malouin, and Ismail Fliss. 2021. "Susceptibility to Nisin, Bactofencin, Pediocin and Reuterin of Multidrug Resistant Staphylococcus aureus, Streptococcus dysgalactiae and Streptococcus uberis Causing Bovine Mastitis" Antibiotics 10, no. 11: 1418. https://doi.org/10.3390/antibiotics10111418

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