Non-Typhoidal Salmonella Infection in Children: Influence of Antibiotic Therapy on Postconvalescent Excretion and Clinical Course—A Systematic Review
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
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First Author, Year of Publication | Country | Type of Study | Pathogen | Patients (Children) 1 | Antibiotics | Influence of Antibiotic Treatment on Excretion | Influence of Antibiotic Treatment on Clinical Course |
---|---|---|---|---|---|---|---|
Macdonald, 1954 [31] | Australia | RCS | S. typhimurium 2 | 51 (100%) | CHL | no influence | no influence |
Dixon, 1965 [32] | England/Wales | RCS | S. typhimurium | 127 (100%) | NEO, STR, AMP, TET, CHL | prolongation | NA |
Rosenstein, 1967 [37] | USA | RCS | NTS | 70 (100%) | AMP, NEO, CHL | prolongation | NA |
Joint Group, 1970 [41] | England | RCT | NTS | 168 (64%) 4 | NEO | prolongation | no difference in duration of symptoms |
Kazemi, 1973 [42] | Canada | RCT | NTS | 36 (100%) | SXT, AMP | no influence | no difference in clinical features or duration of symptoms |
Kazemi, 1974 [49] | Canada | RCS | NTS | 117 (100%) | AMP, PEN, CHL, SXT | prolongation | slight increase in morbidity |
Nelson, 1980 [43] | USA | RCT | NTS 3 | 44 (100%) | AMP, AMX | no influence, but more frequent bacteriologic relapse | no influence on symptoms |
Stögmann, 1982 [44] | Austria | RCS | NTS | 148 (100%) | SXT and/or AMP | no influence | NA |
Chiu, 1997 [48] | Taiwan | PCT | NTS | 30 (100%) | CRO | shortening | no difference in duration of symptoms |
Chiu, 1999 [45] | Taiwan | RCT | NTS | 42 (100%) | AZM, CFM | no influence | no difference in duration of symptoms |
Barbara, 2000 [23] | Italy | PCS | NTS | 1543 (95.1%) | PENs, SXT, CEFs | no influence | higher frequency of persistent symptoms after antibiotic treatment |
Lin, 2003 [46] | Taiwan | PCT | NTS | 73 (100%) | CRO | no influence | longer duration of fever but rapid defervescence after antibiotic treatment |
Tsai, 2011 [13] | Taiwan | RCS | NTS | 683 (100%) | AMP, CHL, SXT, CIP, CRO, FLO, CMF, IPM | NA | shorter hospitalization and duration of fever after treatment with CIP or CRO |
Ho, 2021 [47] | Taiwan | PCS | NTS | 141 (100%) | CRO, SXT, AMP | no influence after appropriate treatment | worse clinical outcome in children with inappropriate antibiotics 5 |
Findings | Conclusions | |
---|---|---|
Influence of antibiotic treatment on NTS excretion | Prolongation in four studies (all published before 1975) | Most recent studies did not observe a prolongation of NTS excretion. |
Prolongation only after inappropriate antibiotic treatment in one study | ||
Shortening in one study | ||
No influence in six studies | ||
Influence of antibiotic treatment on the clinical course of NTS infection | Higher frequency of persistent symptoms in one study | Variable results. Most recent studies did not observe a negative influence of antibiotic treatment on the clinical course. |
Worse clinical outcome only after inappropriate antibiotic treatment in one study | ||
Positive effects in two studies | ||
No influence in six studies |
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Leinert, J.L.; Weichert, S.; Jordan, A.J.; Adam, R. Non-Typhoidal Salmonella Infection in Children: Influence of Antibiotic Therapy on Postconvalescent Excretion and Clinical Course—A Systematic Review. Antibiotics 2021, 10, 1187. https://doi.org/10.3390/antibiotics10101187
Leinert JL, Weichert S, Jordan AJ, Adam R. Non-Typhoidal Salmonella Infection in Children: Influence of Antibiotic Therapy on Postconvalescent Excretion and Clinical Course—A Systematic Review. Antibiotics. 2021; 10(10):1187. https://doi.org/10.3390/antibiotics10101187
Chicago/Turabian StyleLeinert, Johanna L., Stefan Weichert, Alexander J. Jordan, and Rüdiger Adam. 2021. "Non-Typhoidal Salmonella Infection in Children: Influence of Antibiotic Therapy on Postconvalescent Excretion and Clinical Course—A Systematic Review" Antibiotics 10, no. 10: 1187. https://doi.org/10.3390/antibiotics10101187
APA StyleLeinert, J. L., Weichert, S., Jordan, A. J., & Adam, R. (2021). Non-Typhoidal Salmonella Infection in Children: Influence of Antibiotic Therapy on Postconvalescent Excretion and Clinical Course—A Systematic Review. Antibiotics, 10(10), 1187. https://doi.org/10.3390/antibiotics10101187