Next Article in Journal
Clinical Efficacy of Repeated Applications of Local Drug Delivery and Adjunctive Agents in Nonsurgical Periodontal Therapy: A Systematic Review
Next Article in Special Issue
Antibiotics in Orthopedic Infections
Previous Article in Journal
Effect of N-Acetylcysteine in Combination with Antibiotics on the Biofilms of Three Cystic Fibrosis Pathogens of Emerging Importance
Previous Article in Special Issue
Superinfection with Difficult-to-Treat Pathogens Significantly Reduces the Outcome of Periprosthetic Joint Infections
Article

Detailed Revision Risk Analysis after Single- vs. Two-Stage Revision Total Knee Arthroplasty in Periprosthetic Joint Infection: A Retrospective Tertiary Center Analysis

1
Department of Orthopaedic Surgery, Hannover Medical School, Diakovere Annastift, Anna-von-Borries-Str. 1-7, 30625 Hannover, Germany
2
Department of Trauma Surgery, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hanover, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Konstantinos Anagnostakos, Bernd Fink and Jaime Esteban
Antibiotics 2021, 10(10), 1177; https://doi.org/10.3390/antibiotics10101177
Received: 14 August 2021 / Revised: 13 September 2021 / Accepted: 23 September 2021 / Published: 27 September 2021
(This article belongs to the Special Issue Antibiotics in Orthopedic Infections)
Periprosthetic joint infection (PJI) remains one of the most common causes of revision knee arthroplasty. Controversy continues to surround the proper operative technique of PJI in knee arthroplasty with single- or two-stage replacement. Significant variations are seen in the eradication rates of PJI and in implant survival rates. This detailed retrospective analysis of a single tertiary center is intended to provide further data and insight comparing single- and two-stage revision surgery. A retrospective analysis of all revision total knee arthroplasty (TKA) surgeries from 2013 to 2019 was performed and screened with respect to single- or two-stage TKA revisions. Single- and two-stage revisions were analyzed with regard to implant survival, revision rate, microbiological spectrum, and other typical demographic characteristics. A total of 63 patients were included, with 15 patients undergoing single-stage revision and 48 patients undergoing two-stage revision. The mean follow-up time was 40.7 to 43.7 months. Statistically, no difference was found between both groups in overall survival (54.4% vs. 70.1%, p = 0.68) and implant survival with respect to reinfection (71.4% vs. 82.4%, p = 0.48). Further, high reinfection rates were found for patients with difficult-to-treat organisms and low- to semi-constrained implant types, in comparison to constrained implant types. A statistically comparable revision rate for recurrence of infection could be shown for both groups, although a tendency to higher reinfection rate for single-stage change was evident. The revision rate in this single-center study was comparably high, which could be caused by the high comorbidity and high proportion of difficult-to-treat bacteria in patients at a tertiary center. In this patient population, the expectation of implant survival should be critically discussed with patients. View Full-Text
Keywords: periprosthetic joint infection; PJI; single-stage revision TKA; two-stage revision TKA; revision risk; rTKA periprosthetic joint infection; PJI; single-stage revision TKA; two-stage revision TKA; revision risk; rTKA
Show Figures

Figure 1

MDPI and ACS Style

Tuecking, L.-R.; Silligmann, J.; Savov, P.; Omar, M.; Windhagen, H.; Ettinger, M. Detailed Revision Risk Analysis after Single- vs. Two-Stage Revision Total Knee Arthroplasty in Periprosthetic Joint Infection: A Retrospective Tertiary Center Analysis. Antibiotics 2021, 10, 1177. https://doi.org/10.3390/antibiotics10101177

AMA Style

Tuecking L-R, Silligmann J, Savov P, Omar M, Windhagen H, Ettinger M. Detailed Revision Risk Analysis after Single- vs. Two-Stage Revision Total Knee Arthroplasty in Periprosthetic Joint Infection: A Retrospective Tertiary Center Analysis. Antibiotics. 2021; 10(10):1177. https://doi.org/10.3390/antibiotics10101177

Chicago/Turabian Style

Tuecking, Lars-Rene, Julia Silligmann, Peter Savov, Mohamed Omar, Henning Windhagen, and Max Ettinger. 2021. "Detailed Revision Risk Analysis after Single- vs. Two-Stage Revision Total Knee Arthroplasty in Periprosthetic Joint Infection: A Retrospective Tertiary Center Analysis" Antibiotics 10, no. 10: 1177. https://doi.org/10.3390/antibiotics10101177

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop