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A Review on Surface-Enhanced Raman Scattering

1
Department of Chemical Sciences, University of Padova, 35131 Padova, Italy
2
Consorzio INSTM, via G. Giusti 9, 50121 Firenze, Italy
3
Department of Biomedical Engineering, Rutgers University, 599 Taylor Road, Piscataway, NJ 08854, USA
4
Department of Materials Science and Engineering, Rutgers University, 607 Taylor Road, Piscataway, NJ 08854, USA
*
Author to whom correspondence should be addressed.
Biosensors 2019, 9(2), 57; https://doi.org/10.3390/bios9020057
Received: 24 January 2019 / Revised: 9 April 2019 / Accepted: 10 April 2019 / Published: 17 April 2019

Abstract

Surface-enhanced Raman scattering (SERS) has become a powerful tool in chemical, material and life sciences, owing to its intrinsic features (i.e., fingerprint recognition capabilities and high sensitivity) and to the technological advancements that have lowered the cost of the instruments and improved their sensitivity and user-friendliness. We provide an overview of the most significant aspects of SERS. First, the phenomena at the basis of the SERS amplification are described. Then, the measurement of the enhancement and the key factors that determine it (the materials, the hot spots, and the analyte-surface distance) are discussed. A section is dedicated to the analysis of the relevant factors for the choice of the excitation wavelength in a SERS experiment. Several types of substrates and fabrication methods are illustrated, along with some examples of the coupling of SERS with separation and capturing techniques. Finally, a representative selection of applications in the biomedical field, with direct and indirect protocols, is provided. We intentionally avoided using a highly technical language and, whenever possible, intuitive explanations of the involved phenomena are provided, in order to make this review suitable to scientists with different degrees of specialization in this field. View Full-Text
Keywords: SERS; Raman; surface enhanced; electromagnetic enhancement; chemical enhancement; substrates; underpotential deposition; excitation wavelength; biomedical applications; enhancement factor SERS; Raman; surface enhanced; electromagnetic enhancement; chemical enhancement; substrates; underpotential deposition; excitation wavelength; biomedical applications; enhancement factor
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Pilot, R.; Signorini, R.; Durante, C.; Orian, L.; Bhamidipati, M.; Fabris, L. A Review on Surface-Enhanced Raman Scattering. Biosensors 2019, 9, 57.

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