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Biosensors 2017, 7(1), 1;

Versatile Flexible Graphene Multielectrode Arrays

Institute of Bioelectronics (PGI-8/ICS-8), Forschungszentrum Jülich, 52425 Jülich, Germany
Neuroelectronics, Munich School of Bioengineering, Technical University of Munich (TUM), Germany & BCCN Munich, Boltzmannstr. 11, 85748 Garching, Germany
Author to whom correspondence should be addressed.
Academic Editors: Gregory Schneider and Wangyang Fu
Received: 28 October 2016 / Revised: 25 November 2016 / Accepted: 14 December 2016 / Published: 23 December 2016
(This article belongs to the Special Issue Two-Dimensional Layered Biosensors: Versatile Electronics)
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Graphene is a promising material possessing features relevant to bioelectronics applications. Graphene microelectrodes (GMEAs), which are fabricated in a dense array on a flexible polyimide substrate, were investigated in this work for their performance via electrical impedance spectroscopy. Biocompatibility and suitability of the GMEAs for extracellular recordings were tested by measuring electrical activities from acute heart tissue and cardiac muscle cells. The recordings show encouraging signal-to-noise ratios of 65 ± 15 for heart tissue recordings and 20 ± 10 for HL-1 cells. Considering the low noise and excellent robustness of the devices, the sensor arrays are suitable for diverse and biologically relevant applications. View Full-Text
Keywords: graphene; GMEA; graphene electrodes; extracellular recordings; cell-graphene interface graphene; GMEA; graphene electrodes; extracellular recordings; cell-graphene interface

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Kireev, D.; Seyock, S.; Ernst, M.; Maybeck, V.; Wolfrum, B.; Offenhäusser, A. Versatile Flexible Graphene Multielectrode Arrays. Biosensors 2017, 7, 1.

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