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Biosensors 2014, 4(3), 273-300;

Biosensors with Built-In Biomolecular Logic Gates for Practical Applications

Department of Chemistry, Tunghai University, Taichung 40704, Taiwan
Author to whom correspondence should be addressed.
Received: 3 July 2014 / Revised: 15 August 2014 / Accepted: 22 August 2014 / Published: 27 August 2014
(This article belongs to the Special Issue Electrochemical and Biomedical Sensors)
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Molecular logic gates, designs constructed with biological and chemical molecules, have emerged as an alternative computing approach to silicon-based logic operations. These molecular computers are capable of receiving and integrating multiple stimuli of biochemical significance to generate a definitive output, opening a new research avenue to advanced diagnostics and therapeutics which demand handling of complex factors and precise control. In molecularly gated devices, Boolean logic computations can be activated by specific inputs and accurately processed via bio-recognition, bio-catalysis, and selective chemical reactions. In this review, we survey recent advances of the molecular logic approaches to practical applications of biosensors, including designs constructed with proteins, enzymes, nucleic acids, nanomaterials, and organic compounds, as well as the research avenues for future development of digitally operating “sense and act” schemes that logically process biochemical signals through networked circuits to implement intelligent control systems. View Full-Text
Keywords: biosensor; molecular computing; logic gate; biomedical application biosensor; molecular computing; logic gate; biomedical application

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Lai, Y.-H.; Sun, S.-C.; Chuang, M.-C. Biosensors with Built-In Biomolecular Logic Gates for Practical Applications. Biosensors 2014, 4, 273-300.

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