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Biosensors
Volume 15
Issue 8
10.3390/bios15080484
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Review

Organic Afterglow Materials for Tumor Diagnosis and Therapy

by
Xiayi Chen
1,†,
Bin Li
1,†,
Baoli Yin
2,
Dong Xu
1,* and
Youjuan Wang
1,*
1
The Key Laboratory of Zhejiang Province for Basic and Clinical Application of Functional Nucleic Acids, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, China
2
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Biosensors 2025, 15(8), 484; https://doi.org/10.3390/bios15080484
Submission received: 27 May 2025 / Revised: 8 July 2025 / Accepted: 17 July 2025 / Published: 25 July 2025
(This article belongs to the Special Issue Single-Molecule Biosensing: Recent Advances and Future Challenges)
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Abstract

Organic afterglow nanoparticles (OANs) represent a unique class of optical materials capable of sustaining luminescence after excitation cessation. Owing to their exceptional design flexibility, tunable optical properties, and favorable biosafety profiles, OAN-based afterglow imaging has emerged as an advanced modality in tumor diagnosis and therapy. These nanostructures demonstrate significant potential in guiding precision surgical interventions and real-time monitoring of tumor treatment, including photodynamic therapy, photothermal therapy, and immunotherapy. This review systematically analyzes and discusses the luminescence mechanisms of OANs under various excitation sources, with particular emphasis on recent developments in tumor detection and treatment. Additionally, we also discuss the current challenges and future perspectives of using these nanoparticles in this field.
Keywords: afterglow luminescence imaging; organic afterglow nanoparticles; tumor diagnosis and therapy afterglow luminescence imaging; organic afterglow nanoparticles; tumor diagnosis and therapy

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MDPI and ACS Style

Chen, X.; Li, B.; Yin, B.; Xu, D.; Wang, Y. Organic Afterglow Materials for Tumor Diagnosis and Therapy. Biosensors 2025, 15, 484. https://doi.org/10.3390/bios15080484

AMA Style

Chen X, Li B, Yin B, Xu D, Wang Y. Organic Afterglow Materials for Tumor Diagnosis and Therapy. Biosensors. 2025; 15(8):484. https://doi.org/10.3390/bios15080484

Chicago/Turabian Style

Chen, Xiayi, Bin Li, Baoli Yin, Dong Xu, and Youjuan Wang. 2025. "Organic Afterglow Materials for Tumor Diagnosis and Therapy" Biosensors 15, no. 8: 484. https://doi.org/10.3390/bios15080484

APA Style

Chen, X., Li, B., Yin, B., Xu, D., & Wang, Y. (2025). Organic Afterglow Materials for Tumor Diagnosis and Therapy. Biosensors, 15(8), 484. https://doi.org/10.3390/bios15080484

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