Skin-Integrated Wearable Systems and Implantable Biosensors: A Comprehensive Review

Rodrigues, Daniela; Barbosa, Ana I.; Rebelo, Rita; Kwon, Il Keun; Reis, Rui L.; Correlo, Vitor M.

doi:10.3390/bios10070079

Open AccessReview

Skin-Integrated Wearable Systems and Implantable Biosensors: A Comprehensive Review

by

Daniela Rodrigues

¹

,

Ana I. Barbosa

^1,2,

Rita Rebelo

^1,2

,

Il Keun Kwon

¹,

Rui L. Reis

^1,2,3 and

Vitor M. Correlo

^1,2,*

¹

3B’s Research Group, I3Bs—Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal

²

ICVS/3B’s—PT Government Associate Laboratory, 4710-057 Braga, Portugal

³

Department of Dental Materials, School of Dentistry, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea

^*

Author to whom correspondence should be addressed.

Biosensors 2020, 10(7), 79; https://doi.org/10.3390/bios10070079

Submission received: 8 June 2020 / Revised: 7 July 2020 / Accepted: 16 July 2020 / Published: 21 July 2020

(This article belongs to the Section Nano- and Micro-Technologies in Biosensors)

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Abstract

Biosensors devices have attracted the attention of many researchers across the world. They have the capability to solve a large number of analytical problems and challenges. They are future ubiquitous devices for disease diagnosis, monitoring, treatment and health management. This review presents an overview of the biosensors field, highlighting the current research and development of bio-integrated and implanted biosensors. These devices are micro- and nano-fabricated, according to numerous techniques that are adapted in order to offer a suitable mechanical match of the biosensor to the surrounding tissue, and therefore decrease the body’s biological response. For this, most of the skin-integrated and implanted biosensors use a polymer layer as a versatile and flexible structural support, combined with a functional/active material, to generate, transmit and process the obtained signal. A few challenging issues of implantable biosensor devices, as well as strategies to overcome them, are also discussed in this review, including biological response, power supply, and data communication.

Keywords: biosensors; skin-integration; implantable; power supply; data communication

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MDPI and ACS Style

Rodrigues, D.; Barbosa, A.I.; Rebelo, R.; Kwon, I.K.; Reis, R.L.; Correlo, V.M. Skin-Integrated Wearable Systems and Implantable Biosensors: A Comprehensive Review. Biosensors 2020, 10, 79. https://doi.org/10.3390/bios10070079

AMA Style

Rodrigues D, Barbosa AI, Rebelo R, Kwon IK, Reis RL, Correlo VM. Skin-Integrated Wearable Systems and Implantable Biosensors: A Comprehensive Review. Biosensors. 2020; 10(7):79. https://doi.org/10.3390/bios10070079

Chicago/Turabian Style

Rodrigues, Daniela, Ana I. Barbosa, Rita Rebelo, Il Keun Kwon, Rui L. Reis, and Vitor M. Correlo. 2020. "Skin-Integrated Wearable Systems and Implantable Biosensors: A Comprehensive Review" Biosensors 10, no. 7: 79. https://doi.org/10.3390/bios10070079

APA Style

Rodrigues, D., Barbosa, A. I., Rebelo, R., Kwon, I. K., Reis, R. L., & Correlo, V. M. (2020). Skin-Integrated Wearable Systems and Implantable Biosensors: A Comprehensive Review. Biosensors, 10(7), 79. https://doi.org/10.3390/bios10070079

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Skin-Integrated Wearable Systems and Implantable Biosensors: A Comprehensive Review

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