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Developing Protein-Based Nanoparticles as Versatile Delivery Systems for Cancer Therapy and Imaging

1
Department of Molecular Sciences, Macquarie University, Sydney 2109, Australia
2
College of Pharmacy, Korea University, 2511 Sejong-ro, Sejong 30019, Korea
3
Australian Research Council Centre of Excellence for Nanoscale BioPhotonics, Macquarie University, Sydney, NSW 2109, Australia
*
Author to whom correspondence should be addressed.
Nanomaterials 2019, 9(9), 1329; https://doi.org/10.3390/nano9091329
Received: 19 August 2019 / Revised: 4 September 2019 / Accepted: 12 September 2019 / Published: 16 September 2019
(This article belongs to the Special Issue Optical Nanomaterials for Diagnosis and Therapy)
In recent years, it has become apparent that cancer nanomedicine’s reliance on synthetic nanoparticles as drug delivery systems has resulted in limited clinical outcomes. This is mostly due to a poor understanding of their “bio–nano” interactions. Protein-based nanoparticles (PNPs) are rapidly emerging as versatile vehicles for the delivery of therapeutic and diagnostic agents, offering a potential alternative to synthetic nanoparticles. PNPs are abundant in nature, genetically and chemically modifiable, monodisperse, biocompatible, and biodegradable. To harness their full clinical potential, it is important for PNPs to be accurately designed and engineered. In this review, we outline the recent advancements and applications of PNPs in cancer nanomedicine. We also discuss the future directions for PNP research and what challenges must be overcome to ensure their translation into the clinic. View Full-Text
Keywords: drug delivery; nanomedicine; cancer therapy; cancer imaging; virus-like particles; protein-based nanoparticles; synthetic biology drug delivery; nanomedicine; cancer therapy; cancer imaging; virus-like particles; protein-based nanoparticles; synthetic biology
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MDPI and ACS Style

Sandra, F.; Khaliq, N.U.; Sunna, A.; Care, A. Developing Protein-Based Nanoparticles as Versatile Delivery Systems for Cancer Therapy and Imaging. Nanomaterials 2019, 9, 1329.

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