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Flexible HIV-1 Biosensor Based on the Au/MoS2 Nanoparticles/Au Nanolayer on the PET Substrate

Department of Chemical & Biomolecular Engineering, Sogang University, 35 Baekbeom-Ro, Mapo-Gu, Seoul 04107, Korea
Department of Chemical Engineering, Kwangwoon University, Wolgye-dong, Nowon-gu, Seoul 01899, Korea
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nanomaterials 2019, 9(8), 1076;
Received: 9 July 2019 / Revised: 23 July 2019 / Accepted: 24 July 2019 / Published: 26 July 2019
PDF [2693 KB, uploaded 26 July 2019]


An electrochemical flexible biosensor composed of gold (Au), molybdenum disulfide nanoparticles (MoS2 NPs), and Au (Au/MoS2/Au nanolayer) on the polyethylene terephthalate (PET) substrate is developed to detect envelope glycoprotein GP120 (gp120), the surface protein of HIV-1. To fabricate the nanolayer on the PET substrate, Au is sputter coated on the flexible PET substrate and MoS2 NPs are spin coated on Au, which is sputter coated once again with Au. The gp120 antibody is then immobilized on this flexible electrode through cysteamine (Cys) modified on the surface of the Au/MoS2/Au nanolayer. Fabrication of the biosensor is verified by atomic force microscopy, scanning electron microscopy, and cyclic voltammetry. A flexibility test is done using a micro-fatigue tester. Detection of the gp120 is measured by square wave voltammetry. The results indicate that the prepared biosensor detects 0.1 pg/mL of gp120, which is comparable with previously reported gp120 biosensors prepared even without flexibility. Therefore, the proposed biosensor supports the development of a nanomaterial-based flexible sensing platform for highly sensitive biosensors with flexibility for wearable device application. View Full-Text
Keywords: nanolayer; flexible biosensor; HIV-1; MoS2 nanoparticles; PET substrate; gp120 nanolayer; flexible biosensor; HIV-1; MoS2 nanoparticles; PET substrate; gp120

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Shin, M.; Yoon, J.; Yi, C.; Lee, T.; Choi, J.-W. Flexible HIV-1 Biosensor Based on the Au/MoS2 Nanoparticles/Au Nanolayer on the PET Substrate. Nanomaterials 2019, 9, 1076.

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